Microinjection

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Microinjection refers to the process of using a glass micropipette to insert substances at a microscopic or borderline macroscopic level into a single living cell. (Wikipedia.org)






Conferences related to Microinjection

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2021 IEEE International Conference on Mechatronics (ICM)

CM focuses on recent developments and future prospects related to the synergetic integration of mechanics, electronics, and information processing.


2021 IEEE Pulsed Power Conference (PPC)

The Pulsed Power Conference is held on a biannual basis and serves as the principal forum forthe exchange of information on pulsed power technology and engineering.


2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)

The conference program will consist of plenary lectures, symposia, workshops and invitedsessions of the latest significant findings and developments in all the major fields of biomedical engineering.Submitted papers will be peer reviewed. Accepted high quality papers will be presented in oral and postersessions, will appear in the Conference Proceedings and will be indexed in PubMed/MEDLINE


2020 American Control Conference (ACC)

The ACC is the annual conference of the American Automatic Control Council (AACC, the U.S. national member organization of the International Federation for Automatic Control (IFAC)). The ACC is internationally recognized as a premier scientific and engineering conference dedicated to the advancement of control theory and practice. The ACC brings together an international community of researchers and practitioners to discuss the latest findings in automatic control. The 2020 ACC technical program will

  • 2019 American Control Conference (ACC)

    Technical topics include biological systems, vehicle dynamics and control, adaptive control, consensus control, cooperative control, control of communication networks, control of networked systems, control of distributed parameter systems, decentralized control, delay systems, discrete-event systems, fault detection, fault-tolerant systems, flexible structures, flight control, formation flying, fuzzy systems, hybrid systems, system identification, iterative learning control, model predictive control, linear parameter-varying systems, linear matrix inequalities, machine learning, manufacturing systems, robotics, multi-agent systems, neural networks, nonlinear control, observers, optimal control, optimization, path planning, navigation, robust control, sensor fusion, sliding mode control, stochastic systems, switched systems, uncertain systems, game theory.

  • 2018 Annual American Control Conference (ACC)

    Technical topics include biological systems, vehicle dynamics and control, adaptive control, consensus control, cooperative control, control of communication networks, control of networked systems, control of distributed parameter systems, decentralized control, delay systems, discrete-event systems, fault detection, fault-tolerant systems, flexible structures, flight control, formation flying, fuzzy systems, hybrid systems, system identification, iterative learning control, model predictive control, linear parameter-varying systems, linear matrix inequalities, machine learning, manufacturing systems, robotics, multi-agent systems, neural networks, nonlinear control, observers, optimal control, optimization, path planning, navigation, robust control, sensor fusion, sliding mode control, stochastic systems, switched systems, uncertain systems, game theory.

  • 2017 American Control Conference (ACC)

    Technical topics include biological systems, vehicle dynamics and control, adaptive control, consensus control, cooperative control, control of communication networks, control of networked systems, control of distributed parameter systems, decentralized control, delay systems, discrete-event systems, fault detection, fault-tolerant systems, flexible structures, flight control, formation flying, fuzzy systems, hybrid systems, system identification, iterative learning control, model predictive control, linear parameter-varying systems, linear matrix inequalities, machine learning, manufacturing systems, robotics, multi-agent systems, neural networks, nonlinear control, observers, optimal control, optimization, path planning, navigation, robust control, sensor fusion, sliding mode control, stochastic systems, switched systems, uncertain systems, game theory.

  • 2016 American Control Conference (ACC)

    Control systems theory and practice. Conference topics include biological systems, vehicle dynamics and control, consensus control, cooperative control, control of communication networks, control of networked systems, control of distributed parameter systems, decentralized control, delay systems, discrete-event systems, fault detection, fault-tolerant systems, flexible structures, flight control, formation flying, fuzzy systems, hybrid systems, system identification, iterative learning control, model predictive control, linear parameter-varying systems, linear matrix inequalities, machine learning, manufacturing systems, robotics, multi-agent systems, neural networks, nonlinear control, observers, optimal control, optimization, path planning, navigation, robust control, sensor fusion, sliding mode control, stochastic systems, switched systems, uncertain systems, game theory.

  • 2015 American Control Conference (ACC)

    control theory, technology, and practice

  • 2014 American Control Conference - ACC 2014

    All areas of the theory and practice of automatic control, including but not limited to network control systems, model predictive control, systems analysis in biology and medicine, hybrid and switched systems, aerospace systems, power and energy systems and control of nano- and micro-systems.

  • 2013 American Control Conference (ACC)

    Control systems theory and practice. Conference themes on sustainability, societal challenges for control, smart healthcare systems. Conference topics include biological systems, vehicle dynamics and control, consensus control, cooperative control, control of communication networks, control of networked systems, control of distributed parameter systems, decentralized control, delay systems, discrete-event systems, fault detection, fault-tolerant systems, flexible structures, flight control, formation flying, fuzzy systems, hybrid systems, system identification, iterative learning control, model predictive control, linear parameter-varying systems, linear matrix inequalities, machine learning, manufacturing systems, robotics, multi-agent systems, neural networks, nonlinear control, observers, optimal control, optimization, path planning, navigation, robust control, sensor fusion, sliding mode control, stochastic systems, switched systems, uncertain systems, game theory.

  • 2012 American Control Conference - ACC 2012

    All areas of control engineering and science.

  • 2011 American Control Conference - ACC 2011

    ACC provides a forum for bringing industry and academia together to discuss the latest developments in the area of Automatic Control Systems, from new control theories, to the advances in sensors and actuator technologies, and to new applications areas for automation.

  • 2010 American Control Conference - ACC 2010

    Theory and practice of automatic control

  • 2009 American Control Conference - ACC 2009

    The 2009 ACC technical program will cover new developments related to theory, application, and education in control science and engineering. In addition to regular technical sessions the program will also feature interactive and tutorial sessions and preconference workshops.

  • 2008 American Control Conference - ACC 2008

  • 2007 American Control Conference - ACC 2007

  • 2006 American Control Conference - ACC 2006 (Silver Anniversary)

  • 2005 American Control Conference - ACC 2005

  • 2004 American Control Conference - ACC 2004

  • 2003 American Control Conference - ACC 2003

  • 2002 American Control Conference - ACC 2002

  • 2001 American Control Conference - ACC 2001

  • 2000 American Control Conference - ACC 2000

  • 1999 American Control Conference - ACC '99

  • 1998 American Control Conference - ACC '98

  • 1997 American Control Conference - ACC '97

  • 1996 13th Triennial World Congress of the International Federation of Automatic Control (IFAC)


2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI 2020)

The IEEE International Symposium on Biomedical Imaging (ISBI) is the premier forum for the presentation of technological advances in theoretical and applied biomedical imaging. ISBI 2020 will be the 17th meeting in this series. The previous meetings have played a leading role in facilitating interaction between researchers in medical and biological imaging. The 2020 meeting will continue this tradition of fostering cross-fertilization among different imaging communities and contributing to an integrative approach to biomedical imaging across all scales of observation.

  • 2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI)

    The IEEE International Symposium on Biomedical Imaging (ISBI) is the premier forum for the presentation of technological advances in theoretical and applied biomedical imaging.ISBI 2019 will be the 16th meeting in this series. The previous meetings have played a leading role in facilitating interaction between researchers in medical and biological imaging. The 2019 meeting will continue this tradition of fostering cross fertilization among different imaging communities and contributing to an integrative approach to biomedical imaging across all scales of observation.

  • 2018 IEEE 15th International Symposium on Biomedical Imaging (ISBI 2018)

    The IEEE International Symposium on Biomedical Imaging (ISBI) is the premier forum for the presentation of technological advances in theoretical and applied biomedical imaging. ISBI 2018 will be the 15th meeting in this series. The previous meetings have played a leading role in facilitating interaction between researchers in medical and biological imaging. The 2018 meeting will continue this tradition of fostering crossfertilization among different imaging communities and contributing to an integrative approach to biomedical imaging across all scales of observation.

  • 2017 IEEE 14th International Symposium on Biomedical Imaging (ISBI 2017)

    The IEEE International Symposium on Biomedical Imaging (ISBI) is the premier forum for the presentation of technological advances in theoretical and applied biomedical imaging. ISBI 2017 will be the 14th meeting in this series. The previous meetings have played a leading role in facilitating interaction between researchers in medical and biological imaging. The 2017 meeting will continue this tradition of fostering crossfertilization among different imaging communities and contributing to an integrative approach to biomedical imaging across all scales of observation.

  • 2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI 2016)

    The IEEE International Symposium on Biomedical Imaging (ISBI) is the premier forumfor the presentation of technological advances in theoretical and applied biomedical imaging. ISBI 2016 willbe the thirteenth meeting in this series. The previous meetings have played a leading role in facilitatinginteraction between researchers in medical and biological imaging. The 2016 meeting will continue thistradition of fostering crossfertilization among different imaging communities and contributing to an integrativeapproach to biomedical imaging across all scales of observation.

  • 2015 IEEE 12th International Symposium on Biomedical Imaging (ISBI 2015)

    The IEEE International Symposium on Biomedical Imaging (ISBI) is the premier forum for the presentation of technological advances in theoretical and applied biomedical imaging. ISBI 2015 will be the 12th meeting in this series. The previous meetings have played a leading role in facilitating interaction between researchers in medical and biological imaging. The 2014 meeting will continue this tradition of fostering crossfertilization among different imaging communities and contributing to an integrative approach to biomedical imaging across all scales of observation.

  • 2014 IEEE 11th International Symposium on Biomedical Imaging (ISBI 2014)

    The IEEE International Symposium on Biomedical Imaging (ISBI) is the premier forum for the presentation of technological advances in theoretical and applied biomedical imaging. ISBI 2014 will be the eleventh meeting in this series. The previous meetings have played a leading role in facilitating interaction between researchers in medical and biological imaging. The 2014 meeting will continue this tradition of fostering crossfertilization among different imaging communities and contributing to an integrative approach to biomedical imaging across all scales of observation.

  • 2013 IEEE 10th International Symposium on Biomedical Imaging (ISBI 2013)

    To serve the biological, biomedical, bioengineering, bioimaging and other technical communities through a quality program of presentations and papers on the foundation, application, development, and use of biomedical imaging.

  • 2012 IEEE 9th International Symposium on Biomedical Imaging (ISBI 2012)

    To serve the biological, biomedical, bioengineering, bioimaging, and other technical communities through a quality program of presentations and papers on the foundation, application, development, and use of biomedical imaging.

  • 2011 IEEE 8th International Symposium on Biomedical Imaging (ISBI 2011)

    To serve the biological, biomedical, bioengineering, bioimaging, and other technical communities through a quality program of presentations and papers on the foundation, application, development, and use of biomedical imaging.

  • 2010 IEEE 7th International Symposium on Biomedical Imaging (ISBI 2010)

    To serve the biological, biomedical, bioengineering, bioimaging, and other technical communities through a quality program of presentations and papers on the foundation, application, development, and use of biomedical imaging.

  • 2009 IEEE 6th International Symposium on Biomedical Imaging (ISBI 2009)

    Algorithmic, mathematical and computational aspects of biomedical imaging, from nano- to macroscale. Topics of interest include image formation and reconstruction, computational and statistical image processing and analysis, dynamic imaging, visualization, image quality assessment, and physical, biological and statistical modeling. Molecular, cellular, anatomical and functional imaging modalities and applications.

  • 2008 IEEE 5th International Symposium on Biomedical Imaging (ISBI 2008)

    Algorithmic, mathematical and computational aspects of biomedical imaging, from nano- to macroscale. Topics of interest include image formation and reconstruction, computational and statistical image processing and analysis, dynamic imaging, visualization, image quality assessment, and physical, biological and statistical modeling. Molecular, cellular, anatomical and functional imaging modalities and applications.

  • 2007 IEEE 4th International Symposium on Biomedical Imaging: Macro to Nano (ISBI 2007)

  • 2006 IEEE 3rd International Symposium on Biomedical Imaging: Macro to Nano (ISBI 2006)

  • 2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano (ISBI 2004)

  • 2002 1st IEEE International Symposium on Biomedical Imaging: Macro to Nano (ISBI 2002)


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Periodicals related to Microinjection

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Automation Science and Engineering, IEEE Transactions on

The IEEE Transactions on Automation Sciences and Engineering (T-ASE) publishes fundamental papers on Automation, emphasizing scientific results that advance efficiency, quality, productivity, and reliability. T-ASE encourages interdisciplinary approaches from computer science, control systems, electrical engineering, mathematics, mechanical engineering, operations research, and other fields. We welcome results relevant to industries such as agriculture, biotechnology, healthcare, home automation, maintenance, manufacturing, pharmaceuticals, retail, ...


Biomedical Engineering, IEEE Transactions on

Broad coverage of concepts and methods of the physical and engineering sciences applied in biology and medicine, ranging from formalized mathematical theory through experimental science and technological development to practical clinical applications.


Industrial Electronics, IEEE Transactions on

Theory and applications of industrial electronics and control instrumentation science and engineering, including microprocessor control systems, high-power controls, process control, programmable controllers, numerical and program control systems, flow meters, and identification systems.


Industrial Informatics, IEEE Transactions on

IEEE Transactions on Industrial Informatics focuses on knowledge-based factory automation as a means to enhance industrial fabrication and manufacturing processes. This embraces a collection of techniques that use information analysis, manipulation, and distribution to achieve higher efficiency, effectiveness, reliability, and/or security within the industrial environment. The scope of the Transaction includes reporting, defining, providing a forum for discourse, and informing ...


Information Technology in Biomedicine, IEEE Transactions on

Telemedicine, teleradiology, telepathology, telemonitoring, telediagnostics, 3D animations in health care, health information networks, clinical information systems, virtual reality applications in medicine, broadband technologies, and global information infrastructure design for health care.


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Most published Xplore authors for Microinjection

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Xplore Articles related to Microinjection

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Study of micromanipulation using stereoscopic microscope

Proceedings of the 17th IEEE Instrumentation and Measurement Technology Conference [Cat. No. 00CH37066], 2000

In this paper, we describe a visual feedback system using a stereoscopic microscope that controls a micromanipulator so that a needle may pierce a target as much length as desired. At first, for achieving the manipulation at a realistic rate, we proposed a strategy of moving the needle head. Secondarily, we developed an algorithm for prediction of the tip position ...


Chemically actuated microinjectors and programming with a microfluidic network

TRANSDUCERS 2009 - 2009 International Solid-State Sensors, Actuators and Microsystems Conference, 2009

A microfluidic device that works autonomously without external electrical signals was fabricated. The device consisted of chemically actuated microinjectors and microfluidic networks. The operation of the microinjectors was based on the volume change of oxygen bubbles produced as a result of catalytic decomposition of hydrogen peroxide. A hydrogen peroxide solution was transported through a flow channel for programming by capillary ...


Electrowetting-based actuation for microinjection

TRANSDUCERS '03. 12th International Conference on Solid-State Sensors, Actuators and Microsystems. Digest of Technical Papers (Cat. No.03TH8664), 2003

We propose a micro pipette which has a pumping and ejecting function based on the principle of electrowetting on dielectric (EWOD). The pipette was fabricated through a simple process of depositing and patterning conductive materials and hydrophobic polymer coatings on the inside and outside of a pulled glass tube. We estimated the amount of the controllable water theoretically. The pipette ...


Towards ultrahigh throughput microinjection: MEMS-based massively-parallelized mechanoporation

2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2012

We describe a massively-parallelized, MEMS-based device concept for passively delivering exogeneous molecules into living cells via mechanical membrane penetration, i.e., mechanoporation. Details regarding device design and fabrication are discussed, as are results from preliminary live cell studies focused on device validation at the proof-of-concept level. These efforts represent key steps towards our long-term goal of developing instrumentation capable of ultrahigh ...


Fabrication of high-aspect-ratio micro pipettes and fiber probes by sacrificial boundary etch process

The 13th International Conference on Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05., 2005

This paper presents a novel fabrication process to realize high-aspect-ratio micro pipettes and fiber probes which can be used for biological applications. The basic fabrication process employs hydrofluoric acid (HF) to etch the outer layer of the end of capillary tubes and optical fibers as previously reported by other researchers. However, we invented a "sacrificial boundary etching" technique that can ...


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Educational Resources on Microinjection

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IEEE-USA E-Books

  • Study of micromanipulation using stereoscopic microscope

    In this paper, we describe a visual feedback system using a stereoscopic microscope that controls a micromanipulator so that a needle may pierce a target as much length as desired. At first, for achieving the manipulation at a realistic rate, we proposed a strategy of moving the needle head. Secondarily, we developed an algorithm for prediction of the tip position of the needle head within the target. Before the needle pierces the target, the shape of the needle head is preserved as a reference pattern. After the needle piercing the target, the shape of the needle head within the target is predicted using the reference pattern and the tip position of the needle head can be detected. Experimental results indicate that the proposed system may be useful in micromanipulation such as microinjection to seeds.

  • Chemically actuated microinjectors and programming with a microfluidic network

    A microfluidic device that works autonomously without external electrical signals was fabricated. The device consisted of chemically actuated microinjectors and microfluidic networks. The operation of the microinjectors was based on the volume change of oxygen bubbles produced as a result of catalytic decomposition of hydrogen peroxide. A hydrogen peroxide solution was transported through a flow channel for programming by capillary action spontaneously. Following this, the microinjectors were switched on sequentially. Solutions stored in the upper reservoir for the respective microinjectors could be injected into a main flow channel. Timing for triggering the pumping action could be adjusted by changing the length of the programming flow channel for the hydrogen peroxide solution. In other words, information of the program could be written on the device in the form of the network of flow channels.

  • Electrowetting-based actuation for microinjection

    We propose a micro pipette which has a pumping and ejecting function based on the principle of electrowetting on dielectric (EWOD). The pipette was fabricated through a simple process of depositing and patterning conductive materials and hydrophobic polymer coatings on the inside and outside of a pulled glass tube. We estimated the amount of the controllable water theoretically. The pipette was designed to pump up liquid of 50 nl at a driving voltage of 250 V. Capillary rise and depression were then observed in a fabricated pipette.

  • Towards ultrahigh throughput microinjection: MEMS-based massively-parallelized mechanoporation

    We describe a massively-parallelized, MEMS-based device concept for passively delivering exogeneous molecules into living cells via mechanical membrane penetration, i.e., mechanoporation. Details regarding device design and fabrication are discussed, as are results from preliminary live cell studies focused on device validation at the proof-of-concept level. These efforts represent key steps towards our long-term goal of developing instrumentation capable of ultrahigh throughput (UHT) cellular manipulation via active microinjection.

  • Fabrication of high-aspect-ratio micro pipettes and fiber probes by sacrificial boundary etch process

    This paper presents a novel fabrication process to realize high-aspect-ratio micro pipettes and fiber probes which can be used for biological applications. The basic fabrication process employs hydrofluoric acid (HF) to etch the outer layer of the end of capillary tubes and optical fibers as previously reported by other researchers. However, we invented a "sacrificial boundary etching" technique that can be used to shape micron size tubes and fibers into sharp pipettes or probe tips with controllable tip angle. The tip profile and the length of its taper can be controlled by the initial height of the HF inside a glass tube, which is used as a sacrificial material in shaping the tip profile. Our experimental results showed that capillary tubes and optical fibers can be sharpen into tips with angle as small as 2.1/spl deg/ and with tip diameter of ranging from 300 nm to 5 /spl mu/m (the initial tube and fiber diameter being 125 /spl mu/m). If the aspect-ratio (AR) of a pipette is defined as the ratio between the length of its taper distance and the length of its base diameter, the AR for our fabricated pipette can be as high as 10. We also conducted experiments by using the fabricated pipettes to perform microinjection of fluid into cells and fluid ejection to substrates for potential micro-spotting applications.

  • Information Fusing Control of the DNA Microinjection Volume Based on Stochastic Fuzzy Neural Network

    The single-factor controlling accuracy of the DNA microinjection volume by a gaseous-electrical controller is not satisfying by now. A method based on SFNN to fuse controlling factors' information, including injection pressure, time and pipette's size, etc. is presented in this paper, by which the controlling of DNA microinjection volume is improved. The experimental results show that, compared with the single-factor control, the new method is more effective, and less sensitive to the noise in the input parameters' measurement.

  • Adherent cells localization based on Gaussian filtering in automated microinjection system

    This work is based on the cells in the microinjection system to process adherent cells image. Performing low-pass filtering to the Image of adherent cells, removing uneven illumination, segmenting foreground and background, removing invalid small areas, operating opening and closing operation, keeping the target area, calibrating centers of the cells in the original image.

  • Modeling of quantitative microinjection and adaptive control

    Aiming at the requirements of the controllability and accuracy of microinjection volume in the cell microinjection technique with the micromanipulator, the lumped model of microinjection pipette is proposed, and based on this model, the adaptive control of microinjection mass flow is designed. Starting from the experimental results, the lumped model from electric circuit was borrowed, which describe the relationship between microinjection mass flow and pressure. Through the analysis of variation of each parameter of Lumped model, the multiple forms of the lumped model is obtained and verified. Because of the combined effect of many factors, it is difficult to obtain the specific values of parameters before the experiment. The adaptive control is used to parameter estimation and tracking the microinjection mass flow. At the end of this paper, the controller is used by matlab simulink to simulation and exactly control of injection volume.

  • Micro-Injection System for Localized Drug Delivery Using Embedded Solid Chemical Propellant

    This paper presents a novel micro-injection system for localized drug delivery using embedded solid chemical propellant, azobisisobutyronitrile (AIBN). This system consists of in-plane type of microneedles, a drug reservoir, a chemical fluid source, a chemical fluid source chamber, and a microheater. The AIBN decomposes and produces nitrogen gas and a free radical at about 70 V. Using this phenomenon, the AIBN on the microheater generates nitrogen gas by supplying an electrical power, and then the generated nitrogen gas injects a drug in the drug reservoir through the micro channel buried at the microneedles. This micro-injection system injects 2.29 ~ 2.9 mul blue ink during about 6 seconds by supplying 30.4 V and 164 mA. This novel injection system is expected to be applicable to the highly precise biological equipments.

  • Large-scale high-performance cell membrane perforation, with nanoimprinted mass producible perforator

    The importance of developing methods in which certain materials can be introduced into a group of cells has been gaining considerable attention. However, owing to safety concerns accompanying the use of conventional viral- vector-based transfection and the low efficiency of plasmid-vector-based transfection, the development of a high performance nonbiological method has been expected. Currently available nonbiological methods such as electroporation generally have a low success rate and limited to low- molecular-weight molecules. For other methods that employ cellar uptake like phagocytosis, such as the cationic liposome method, these efficiencies largely depend on the nature of the target cells. In contrast, we found that submicron level cell membrane perforations could be made by inducing the local oxidations in the cell membrane while most of the treated cells were viable. We applied the perforation to the microinjection method and found that the injection of a functional dye, an antibody, and mRNA to the cells resulted in almost 100% survival as well as the successful manifestation of individual functions of these injected molecules. In the recent study, we extended the perforation process in a large number of cells. A nanobrush-shaped soft- polymer sheets formed by the nanoimprinting, which contained a photosensitizer, are used as the cell membrane perforator. We could automate the process by the robotics technology for the high-throughput operation. In future studies, we will extend the cell processing system for multi-purpose practical instruments for e.g. novel cell therapy, systematic cell differentiation.



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