Electrophysiology

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Electrophysiology (from Greek ἥλεκτρον, ēlektron, "amber"; φύσις, physis, "nature, origin"; and -λογία, -logia) is the study of the electrical properties of biological cells and tissues. (Wikipedia.org)


Conferences related to Electrophysiology

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2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII)

The world's premiere conference in MEMS sensors, actuators and integrated micro and nano systems welcomes you to attend this four-day event showcasing major technological, scientific and commercial breakthroughs in mechanical, optical, chemical and biological devices and systems using micro and nanotechnology.The major areas of activity in the development of Transducers solicited and expected at this conference include but are not limited to: Bio, Medical, Chemical, and Micro Total Analysis Systems Fabrication and Packaging Mechanical and Physical Sensors Materials and Characterization Design, Simulation and Theory Actuators Optical MEMS RF MEMS Nanotechnology Energy and Power


2019 41st Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)

The conference program will consist of plenary lectures, symposia, workshops andinvitedsessions of the latest significant findings and developments in all the major fields ofbiomedical engineering.Submitted papers will be peer reviewed. Accepted high quality paperswill be presented in oral and postersessions, will appear in the Conference Proceedings and willbe indexed in PubMed/MEDLINE & IEEE Xplore


2019 IEEE International Ultrasonics Symposium (IUS)

The conference covers all aspects of the technology associated with ultrasound generation and detection and their applications.


ICASSP 2019 - 2019 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)

ICASSP is the world’s largest and most comprehensive technical conference focused on signal processing and its applications. The conference will feature world-class presentations by internationally renowned speakers, cutting-edge session topics and provide a fantastic opportunity to network with like-minded professionals from around the world.


2018 IEEE 18th International Conference on Nanotechnology (IEEE-NANO)

Nanotechnology


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Periodicals related to Electrophysiology

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Applied Superconductivity, IEEE Transactions on

Contains articles on the applications and other relevant technology. Electronic applications include analog and digital circuits employing thin films and active devices such as Josephson junctions. Power applications include magnet design as well asmotors, generators, and power transmission


Audio, Speech, and Language Processing, IEEE Transactions on

Speech analysis, synthesis, coding speech recognition, speaker recognition, language modeling, speech production and perception, speech enhancement. In audio, transducers, room acoustics, active sound control, human audition, analysis/synthesis/coding of music, and consumer audio. (8) (IEEE Guide for Authors) The scope for the proposed transactions includes SPEECH PROCESSING - Transmission and storage of Speech signals; speech coding; speech enhancement and noise reduction; ...


Biomedical Circuits and Systems, IEEE Transactions on

The Transactions on Biomedical Circuits and Systems addresses areas at the crossroads of Circuits and Systems and Life Sciences. The main emphasis is on microelectronic issues in a wide range of applications found in life sciences, physical sciences and engineering. The primary goal of the journal is to bridge the unique scientific and technical activities of the Circuits and Systems ...


Biomedical Engineering, IEEE Reviews in

The IEEE Reviews in Biomedical Engineering will review the state-of-the-art and trends in the emerging field of biomedical engineering. This includes scholarly works, ranging from historic and modern development in biomedical engineering to the life sciences and medicine enabled by technologies covered by the various IEEE societies.


Biomedical Engineering, IEEE Transactions on

Broad coverage of concepts and methods of the physical and engineering sciences applied in biology and medicine, ranging from formalized mathematical theory through experimental science and technological development to practical clinical applications.


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Xplore Articles related to Electrophysiology

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Simulating Cardiac Ventricular Action Potentials in Rat and Mouse

2005 IEEE Engineering in Medicine and Biology 27th Annual Conference, 2006

We have developed a computational model for the rat cardiac ventricular cell by using electrophysiology data. Our control model (Pandit et al., 2001). The model represents the bioelectric activity in the left ventricular cells in adult male rats. We have described the differences in the membrane properties within the left ventricle to simulate the action potential variations of the endocardial ...


Model-based approach to the localization of infarction

2007 Computers in Cardiology, 2007

A model-based approach to noninvasively determine the location and size of the infarction scar is proposed, that in addition helps to estimate the risk of arrhythmias. The approach is based on the optimization of an electrophysiological heart model with an introduced infarction scar to fit the multichannel ECG measured on the surface of the patient's thorax. This model delivers the ...


Evoked EEG gamma band response at slow rates of stimulation

1992 14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 1992

We have sought to confirm the observations of an auditory gamma band response and study the effects associated with several stimulation parameters including ear of stimulation, stimulus intensity and frequency, and rate of repetition. The data confirm the presence of a burst of activity, within the gamma band, following auditory stimuli and suggest that the response is intimately, and specifically, ...


Single-unit and polygraphic recordings in the awake, anaesthetic-free and head-restrained rat

1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.00EX451), 2000

In vivo investigation of the central nervous system is subject to interference with anaesthetic agents. Their influence on neural activity during electrophysiological recordings can be bypassed using a pre-implanted animal model, developed in the authors' laboratory. In this model, the preimplantation on the skull of a light device for further stereotaxic frame attachment allows, after a contention habituation period, classical ...


Implementation and verification of sinoatrial node math model

Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439), 2003

A math model of the sinoatrial node (SAN) is presented, based in last experimental results in literature. This model was proposed by H. Zhang, A. V. Holden and M.R. Boyett and was implemented and verified in order to obtain a better understanding of the processes associated with generation and propagation of action potentials into the mammal sinoatrial node. Math models ...


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Educational Resources on Electrophysiology

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IEEE.tv Videos

IEEE-USA E-Books

  • Simulating Cardiac Ventricular Action Potentials in Rat and Mouse

    We have developed a computational model for the rat cardiac ventricular cell by using electrophysiology data. Our control model (Pandit et al., 2001). The model represents the bioelectric activity in the left ventricular cells in adult male rats. We have described the differences in the membrane properties within the left ventricle to simulate the action potential variations of the endocardial and epicardial cells. We also developed a right ventricular cell model from our control model (the left ventricular cell model) to study ionic mechanisms in diabetic rats (Pandit et al., 2003) Our right ventricular cell model was also the template for us to develop a mouse ventricular cell model by using experimental data. The simulation studies in our models of the rat and mouse ventricular cells conclude that (1) the action potential changes in the left and right ventricles of the normal, diabetic, aged or spontaneously hypertensive rats is mainly due to differences in the 4AP sensitive, Ca<sup>2+</sup> independent transient outward K<sup>+</sup> current (I<sub>t</sub>) current, and (2) the presence of the 4AP sensitive, slowly inactivating, delayed rectifier K <sup>+</sup> current (I<sub>Kslow</sub>) in mouse is one of the main factors contributing to the faster rate of repolarization seen in mouse compared to rats

  • Model-based approach to the localization of infarction

    A model-based approach to noninvasively determine the location and size of the infarction scar is proposed, that in addition helps to estimate the risk of arrhythmias. The approach is based on the optimization of an electrophysiological heart model with an introduced infarction scar to fit the multichannel ECG measured on the surface of the patient's thorax. This model delivers the distributions of transmembrane voltages (TMV) within the ventricles during a single heart cycle. The forward problem of electrocardiography is solved in order to obtain the simulated ECG of the patient. This ECG is compared with the measured one, the difference is used as the criterion for optimization of model parameters, which include the site and size of infarction scar.

  • Evoked EEG gamma band response at slow rates of stimulation

    We have sought to confirm the observations of an auditory gamma band response and study the effects associated with several stimulation parameters including ear of stimulation, stimulus intensity and frequency, and rate of repetition. The data confirm the presence of a burst of activity, within the gamma band, following auditory stimuli and suggest that the response is intimately, and specifically, related to fundamental auditory processes.

  • Single-unit and polygraphic recordings in the awake, anaesthetic-free and head-restrained rat

    In vivo investigation of the central nervous system is subject to interference with anaesthetic agents. Their influence on neural activity during electrophysiological recordings can be bypassed using a pre-implanted animal model, developed in the authors' laboratory. In this model, the preimplantation on the skull of a light device for further stereotaxic frame attachment allows, after a contention habituation period, classical electrophysiological approaches in the central nervous system of anaesthetic free-rats, The use of this model is compatible with repetitive single unit recordings. These experiments may be associated with other electrophysiological or physiological recordings such as electroencephalogram and electromyogram (EEG, EMG) or systemic/local pharmacological challenges (iontophoresis, pneumatic ejection). This technique allowed the authors to record simultaneously cortical activity and firing activity of basal ganglia neurones involved in movement disorders such as Parkinson's disease. The authors describe time-locked changes in firing pattern of subthalamic nucleus cells and cortical activity during vigilance state transitions in the normal rat.

  • Implementation and verification of sinoatrial node math model

    A math model of the sinoatrial node (SAN) is presented, based in last experimental results in literature. This model was proposed by H. Zhang, A. V. Holden and M.R. Boyett and was implemented and verified in order to obtain a better understanding of the processes associated with generation and propagation of action potentials into the mammal sinoatrial node. Math models are used to investigate the ionic base that supports the pacemaker activity in central and periphery cells of SAN. This implementation is the support to develop a sensitivity analysis in the model as the next step in the investigation line.

  • Attention Deficits In Alcoholic Brain Syndrome

    None

  • A Portable REM-Detecting Machine

    A portable electronic device has been developed that successfully detects rapid eye movement (REM) in sleeping subjects. The development was aimed at exploiting the high correlation between a subject's ability to recall dreams and his abrupt awakening a short time after the onset of REM sleep. The device is of clinical interest as a means of increasing the amount of raw dream material available for patients in psychoanalysis.

  • System for electrophysiology integration with other departments using clinical document architecture technologies and HL7 V3

    In the electrophysiology laboratory (EPH-Lab) data collection of implanted devices is mandatory for documentation and clinical reporting. At present, computerized systems are not commonly used in the EPH-Lab, but they can allow clinicians to obtain a proper documentation from an integrated information system, gathering data from ambulatory activity, wards and EPH-Lab archives. The aim of our work was to create an informative system to exchange clinical information using HL7 clinical document architecture (CDA) release 2, defined in HL7 V3 standard. EPH-Lab facility has been introduced as part of our hemodynamic information system (SIE) in order to track work flow, device implantations, electrophysiologic studies, interventional electrophysiology procedures and electronic medical records for anesthesiology.

  • Nerve growth factor dependent changes in electrophysiology measured in a neurotrophic electrode

    We describe here a neurotrophic electrode designed to improve long-term reliability and signal-to-noise in a brain-device interface. Our electrode consists of a fine microwire inside a polyimide tube. The polyimide tube is filled with nerve growth factor (NGF) incorporated into a fibrin matrix. Our goal is to have a neurite grow into the tube. The close apposition between neurite and the recording wire should enhance signal-to-noise. The physical connection between device and tissue should improve reliability. We have implanted complete devices in 4 rats. Each rat gets a four-electrode device implanted in the barrel cortex of each hemisphere. Each electrode is filled with a different test substance. One control tube contains only saline, and another contains only the fibrin matrix. The other two electrodes in each array are filled with different concentrations of NGF. Once weekly following the implant, each rat is sedated, and electrical activity in each of the electrodes recorded. Electrodes in 5 of the 8 implants exhibited multi-unit spindling activity. A direct comparison of the amplitude of action potentials over time in each of the types of implants shows that the presence of NGF within the polyimide tube leads to an increase in action potential amplitude.

  • Micro electrical impedance spectroscopy of bovine chromaffin cells

    Single cell characterization using electrical impedance spectroscopy (EIS) has been conducted on bovine chromaffin cells. Measurements were taken using a micro scale electrophysiological analysis system fabricated using micromachining (e.g. MEMS) technologies. A population of chromaffin cells were injected into a microreservoir and subsequently manipulated into a microchannel with a cross-sectional area of 7.0/spl times/7.0 /spl mu/m/sup 2/. The microchannel was designed with integrated, opposing electroplated palladium electrodes with a cross-sectional area of 7.0/spl times/7.0 /spl mu/m/sup 2/. The electrodes are designed to be in contact with the cells during analysis procedures. Impedance measurements were taken over a frequency range of 40 Hz to 3.0 MHz. Magnitude and phase were studied for a statistically relevant population of chromaffin cells. The impedance spectrums revealed three distinct populations of chromaffin cells. The data obtained for the chromaffin cells was compared to data obtained for red blood cells, air, and phosphate buffered solution.


Standards related to Electrophysiology

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