Artificial biological organs
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The ACC is the annual conference of the American Automatic Control Council (AACC, the U.S. national member organization of the International Federation for Automatic Control (IFAC)). The ACC is internationally recognized as a premier scientific and engineering conference dedicated to the advancement of control theory and practice. The ACC brings together an international community of researchers and practitioners to discuss the latest findings in automatic control. The 2020 ACC technical program will
The conference program will consist of plenary lectures, symposia, workshops and invitedsessions of the latest significant findings and developments in all the major fields of biomedical engineering.Submitted papers will be peer reviewed. Accepted high quality papers will be presented in oral and postersessions, will appear in the Conference Proceedings and will be indexed in PubMed/MEDLINE
The International Conference on Image Processing (ICIP), sponsored by the IEEE SignalProcessing Society, is the premier forum for the presentation of technological advances andresearch results in the fields of theoretical, experimental, and applied image and videoprocessing. ICIP 2020, the 27th in the series that has been held annually since 1994, bringstogether leading engineers and scientists in image and video processing from around the world.
2020 IEEE International Symposium on Circuits and Systems (ISCAS)
The International Symposium on Circuits and Systems (ISCAS) is the flagship conference of the IEEE Circuits and Systems (CAS) Society and the world’s premier networking and exchange forum for researchers in the highly active fields of theory, design and implementation of circuits and systems. ISCAS2020 focuses on the deployment of CASS knowledge towards Society Grand Challenges and highlights the strong foundation in methodology and the integration of multidisciplinary approaches which are the distinctive features of CAS contributions. The worldwide CAS community is exploiting such CASS knowledge to change the way in which devices and circuits are understood, optimized, and leveraged in a variety of systems and applications.
The International Conference on Robotics and Automation (ICRA) is the IEEE Robotics and Automation Society’s biggest conference and one of the leading international forums for robotics researchers to present their work.
Experimental and theoretical advances in antennas including design and development, and in the propagation of electromagnetic waves including scattering, diffraction and interaction with continuous media; and applications pertinent to antennas and propagation, such as remote sensing, applied optics, and millimeter and submillimeter wave techniques.
The theory, design and application of Control Systems. It shall encompass components, and the integration of these components, as are necessary for the construction of such systems. The word `systems' as used herein shall be interpreted to include physical, biological, organizational and other entities and combinations thereof, which can be represented through a mathematical symbolism. The Field of Interest: shall ...
The Transactions on Biomedical Circuits and Systems addresses areas at the crossroads of Circuits and Systems and Life Sciences. The main emphasis is on microelectronic issues in a wide range of applications found in life sciences, physical sciences and engineering. The primary goal of the journal is to bridge the unique scientific and technical activities of the Circuits and Systems ...
Broad coverage of concepts and methods of the physical and engineering sciences applied in biology and medicine, ranging from formalized mathematical theory through experimental science and technological development to practical clinical applications.
Specific topics of interest include, but are not limited to, sequence analysis, comparison and alignment methods; motif, gene and signal recognition; molecular evolution; phylogenetics and phylogenomics; determination or prediction of the structure of RNA and Protein in two and three dimensions; DNA twisting and folding; gene expression and gene regulatory networks; deduction of metabolic pathways; micro-array design and analysis; proteomics; ...
2013 13th IEEE International Conference on Nanotechnology (IEEE-NANO 2013), 2013
The technique to construct the artificial organ made of cultured cells is required in many fields such as tissue engineering and drug development. However, the tissue-like construction more than 200 μm thick has central hypoxia and results in necrosis because of the limitation of diffusion of materials. Then, we will propose a method to form a tissue-like construction including vascular ...
IEEE Engineering in Medicine and Biology Magazine, 1982
The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2004
The mechanical circulatory support system using moving-actuator mechanisms were developed by Seoul National University and Korea University. AnyHeart is a fully implanted pulsatile bi-ventricular assist device, and T-PLS is a pulsatile flow versatile extracorporeal life support system. Through lots of in-vitro and in-vivo experiments, the developed mechanical systems are faced to produce on commercial scale. This paper describes the recent ...
2007 International Symposium on Micro-NanoMechatronics and Human Science, 2007
The regenerative therapy ultimately aims to develop bioengineered organs that can replace lost or damaged organs following disease, injury or aging. Recently, we showed that the artificial organ germ, which generates a structurally correct tooth, could be reconstituted by in vitro cell manipulation (Nature Methods 4, 227-230, 2007). In this study, we revealed that neural crest-like cells, which were differentiated ...
Proceedings of the First Joint BMES/EMBS Conference. 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Annual Fall Meeting of the Biomedical Engineering Society (Cat. N, 1999
Mechanical blood trauma is still one of the major obstacles in the development of cardiovascular devices. The mechanisms of this blood damage are heterogeneous and are not completely identified. Experimental and computational studies were performed to elucidate the role of turbulent stresses in hemolysis. For the experimental study suspensions of bovine red blood cells (RBCs) in saline or in dextran ...
Implantable Wireless Medical Devices and Systems
Workshop on Human-Swarm Interaction-ICRA 2020
EMBC 2011-Workshop- Biological Micro Electro Mechanical Systems (BioMEMS): Fundamentals and Applications-Mehmet R. Dokmeci
Continuously Learning Neuromorphic Systems with High Biological Realism: IEEE Rebooting Computing 2017
EMBC 2011-Workshop-Biological Micro Electro Mechanical Systems (BioMEMS): Fundamentals and Applications-Michelle Khine
EMBC 2011-Keynote Lecture-Engineering Drug Dosing in Dynamic Biological Systems - David J. Balaban
EMBC 2011-Workshop- Biological Micro Electro Mechanical Systems (BioMEMS): Fundamentals and Applications-Utkan Demirci
EMBC 2011-Workshop- Biological Micro Electro Mechanical Systems (BioMEMS): Fundamentals and Applications-Ali Khademhosseini
EMBC 2011-Program-Systems in Synthetic Biology (Part I)-Pamela A. Silver
Engineering the Future - Frances Arnold, Ph.D.
Life Sciences Grand Challenge Conference - Roger Kamm
Introducing DAGSI Whegs
Q&A with Dr. Al Emondi: IEEE Brain Podcast, Episode 13
Feeding the Machine: The World's Most Sophisticated Artificial Stomach
Artificial Neural Networks, Intro
Robotics History: Narratives and Networks Oral Histories: John McCarthy
A Model of Embodied Computation for Artificial Morphogenesis
Honors 2020: Borys Paton Wins the IEEE Honorary Membership
EMBC 2012 Theme Speaker: Dr. James Bassingthwaighte
The technique to construct the artificial organ made of cultured cells is required in many fields such as tissue engineering and drug development. However, the tissue-like construction more than 200 μm thick has central hypoxia and results in necrosis because of the limitation of diffusion of materials. Then, we will propose a method to form a tissue-like construction including vascular network in itself. Biocompatible artificial vessel was wrapped in cell-sheet cocultivated with HUVEC and NIH3T3. Culture medium perfused into the artificial vessel will be diffused into the whole construction through vascular network of HUVEC. This technique will be increases the viability of the cells in the construction.
The mechanical circulatory support system using moving-actuator mechanisms were developed by Seoul National University and Korea University. AnyHeart is a fully implanted pulsatile bi-ventricular assist device, and T-PLS is a pulsatile flow versatile extracorporeal life support system. Through lots of in-vitro and in-vivo experiments, the developed mechanical systems are faced to produce on commercial scale. This paper describes the recent progress of two mechanical circulatory support systems, AnyHeart and T-PLS.
The regenerative therapy ultimately aims to develop bioengineered organs that can replace lost or damaged organs following disease, injury or aging. Recently, we showed that the artificial organ germ, which generates a structurally correct tooth, could be reconstituted by in vitro cell manipulation (Nature Methods 4, 227-230, 2007). In this study, we revealed that neural crest-like cells, which were differentiated from pluripotent stem cells such as embryonal carcinoma (EC) cells, could develop the regenerated tooth by organ germ method with tooth germ epithelium. EC cells were stimulated with dimethyl sulfoxide (DMSO) and differentiated cells were isolated by cell sorting as DMSO-EC cells. We found that the expressions of pluripotent stem cell marker genes (Oct3/4 and Nanog) could not be detected in DMSO-EC cells. In contrast, the expressions of neural crest-marker genes (Pax3 and Slug) and of dental mesenchyme-marker genes (Msxl, Pax9 and Lhx7) increased in DMSO-EC cells, compared with those in EC cells. Furthermore, the structurally correct tooth can be generated by combining DMSO-EC cells and tooth germ epithelium, both in vitro and in vivo. Our current results indicated the possibility that pluripotent stem cells are applicable as a candidate of cell sources to develop of a bioengineered organ germ for the organ replacement in the future regenerative therapy.
Mechanical blood trauma is still one of the major obstacles in the development of cardiovascular devices. The mechanisms of this blood damage are heterogeneous and are not completely identified. Experimental and computational studies were performed to elucidate the role of turbulent stresses in hemolysis. For the experimental study suspensions of bovine red blood cells (RBCs) in saline or in dextran solution were driven through a closed circulating loop by a centrifugal pump. A small capillary tube with the inner diameter of 1 mm and the length of 50 mm was incorporated into loop with tapered connectors. It was shown that, at the same wall shear stress, the level of hemolysis is significantly higher under turbulent flow conditions than laminar flow conditions. This demonstrated that turbulent stresses contribute strongly to blood trauma. These results concurred with predicted hemolysis by computational fluid dynamics (CFD) modeling of the same blood flow conditions.
Removal of anti-A and anti-B blood group antibodies from human blood has been shown to facilitate cross-matched kidney transplantation by preventing hyperacute rejection. Patients had anti-A and anti-B antibodies removed using plasmapheresis followed by immunoadsorption onto packed bead columns. The authors' group conducted pilot studies to assess the feasibility of selectively removing anti-A and anti-B antibodies directly from blood using modified dialysis filters. An anti-A and anti-B specific antigen was covalently attached to the lumenal surface of hollow fibers within selected commercial dialysis modules. The filters were able to reduce the anti-A and anti-B filters of 300 ml of blood to 2 or below. A low molecular weight fraction of the authors' antigen system was found to have no antibody binding capacity. The standard antigen was purified by removal of the low molecular weight fraction and a dialysis filter was modified using the purified antigen. This filter displayed a six-fold higher capacity than a dialysis filter modified with the same mass of standard antigen. Hence the authors expect that a dialysis filter modified with purified antigen at optimal antigen binding conditions may be able to significantly reduce the anti-A and anti-B filters of 2 L of blood. It is concluded that selective blood group antibody removal by antigen-modified dialysis filters is feasible and may be a simpler system than plasmapheresis followed by immunoadsorption.
Continuous flow rotary blood pumps have been developed for decades due to the limited heart donors. Both axial and centrifugal flow types have been developed. In this study, an axial flow blood pump is studied, and the main focus is on the impeller optimization. Totally, nine impeller designs have been studied. It has been found that both the blade height and wrap angle of the impeller affect the hydraulic and hematological performances.
The axial flow pump has been developed in Korea Artificial Organ Center. It consists of an impeller, a motor and a magnetic bearing. The magnetic bearing fully levitates the impeller not to contact with other parts of pump. However, in order to control the gap between the impeller and other parts, continuous gap sensing is necessary. The conventional gap sensors are relatively large to implant in artificial heart. Thus, the compact eddy current sensor system proper for artificial heart was developed and the performances were evaluated. It showed good results and has small size. However, the dependency of the sensor upon temperature and target material was shown also. Moreover, the output of sensor had nonlinear responses. These must be calibrated in further study
In order to lengthen the service life of artificial organs ,blood can be used as lubricant in artificial organs.For the purpose of studying on the influenced factors to blood lubricating properties,especially how much the component of blood can affect blood lubricating properties. In this paper, the blood lubricating properties of four kinds of hematocrit were studied by the friction tester. The worn spots and the adsorption films formed on the steel ball were observed through the Leica DMI 5000 M material Microscope. It was found that: (1) the microshape of the lubricant film depends on the hematocrit; (2) the higher blood's hematocrit is, the smaller worn spots formed on the steel ball become. It is concluded that the higher the hematocrit is, the larger the lubricant film's bearing capacity appears.
The centrifugal blood pump is mostly used in medical field. The ventricular assist devices (VADs) based on CBPs become famous modality for treatment heart failure's patients. However, The CBP has reported that cause of hemolysis and thrombosis in long term used. So, CBP factors that cause of both hemolysis and thrombosis is relating with shear stress at internal surface of CBP; High shear stress cause hemolysis and less shear stress cause thrombosis. In this study, the design of CBP has been developed in order to solve effects from high shear stress. The objective of this study is to describe the design of two types of impellers; backward impeller and Backward with under blade cut impeller. Each designed impellers are compared its effect on shear stress to determine the pro per impeller for decreasing high shear stress of blood pump. Shear stress should less than 300 Pascal in order to reduce hemolysis. Computational Fluid Dynamics (CFD) is calculated pump performance and shear stress comparing to impellers at pump speeds: 1, 1.5, 2, 2.5, 3, and 3.5 krpm. Result, the backward impeller at 2.5 krpm can produce flow rate equal to 5 liter/min and head pressure is 125 mmHg. The backward with under blade cut impeller at 3.5 krpm can produce flow rate of 5 liter/min against pressure head of 81 mmHg. All of impeller design can generate flow rate equal to 5 liter/min against of 80-125 mmHg which is the amount of body requirement. The histogram plot show that the shear stress increases when the rotational speed is increase. In this study, the backward impeller shows the lower shear stress and higher head pressure. Therefore, the backward impeller is better than backward with under blade cut impeller.
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