Conferences related to Biochemical analysis

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2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)

The conference program will consist of plenary lectures, symposia, workshops and invitedsessions of the latest significant findings and developments in all the major fields of biomedical engineering.Submitted papers will be peer reviewed. Accepted high quality papers will be presented in oral and postersessions, will appear in the Conference Proceedings and will be indexed in PubMed/MEDLINE


2020 57th ACM/ESDA/IEEE Design Automation Conference (DAC)

The world's premier EDA and semiconductor design conference and exhibition. DAC features over 60 sessions on design methodologies and EDA tool developments, keynotes, panels, plus the NEW User Track presentations. A diverse worldwide community representing more than 1,000 organizations attends each year, from system designers and architects, logic and circuit designers, validation engineers, CAD managers, senior managers and executives to researchers and academicians from leading universities.

  • 2022 59th ACM/ESDA/IEEE Design Automation Conference (DAC)

    The world's premier EDA and semiconductor design conference and exhibition. DAC features over 60 sessions on design methodologies and EDA tool developments, keynotes, panels, plus the NEW User Track presentations. A diverse worldwide community representing more than 1,000 organizations attends each year, from system designers and architects, logic and circuit designers, validation engineers, CAD managers, senior managers and executives to researchers and academicians from leading universities.

  • 2021 58th ACM/ESDA/IEEE Design Automation Conference (DAC)

    The world's premier EDA and semiconductor design conference and exhibition. DAC features over 60 sessions on design methodologies and EDA tool developments, keynotes, panels, plus the NEW User Track presentations. A diverse worldwide community representing more than 1,000 organizations attends each year, from system designers and architects, logic and circuit designers, validation engineers, CAD managers, senior managers and executives to researchers and academicians from leading universities.

  • 2019 56th ACM/ESDA/IEEE Design Automation Conference (DAC)

    EDA (Electronics Design Automation) is becoming ever more important with the continuous scaling of semiconductor devices and the growing complexities of their use in circuits and systems. Demands for lower-power, higher-reliability and more agile electronic systems raise new challenges to both design and design automation of such systems. For the past five decades, the primary focus of research track at DAC has been to showcase leading-edge research and practice in tools and methodologies for the design of circuits and systems.

  • 2018 55th ACM/ESDA/IEEE Design Automation Conference (DAC)

    The world's premier EDA and semiconductor design conference and exhibition. DAC features over 60 sessions on design methodologies and EDA tool developments, keynotes, panels, plus the NEW User Track presentations. A diverse worldwide community representing more than 1,000 organizations attends each year, from system designers and architects, logic and circuit designers, validation engineers, CAD managers, senior managers and executives to researchers and academicians from leading universities.

  • 2017 54th ACM/EDAC/IEEE Design Automation Conference (DAC)

    The world's premier EDA and semiconductor design conference and exhibition. DAC features over 60 sessions on design methodologies and EDA tool developments, keynotes, panels, plus the NEW User Track presentations. A diverse worldwide community representing more than 1,000 organizations attends each year, from system designers and architects, logic and circuit designers, validation engineers, CAD managers, senior managers and executives to researchers and academicians from leading universities.

  • 2016 53nd ACM/EDAC/IEEE Design Automation Conference (DAC)

    The world's premier EDA and semiconductor design conference and exhibition. DAC features over 60 sessions on design methodologies and EDA tool developments, keynotes, panels, plus the NEW User Track presentations. A diverse worldwide community representing more than 1,000 organizations attends each year, from system designers and architects, logic and circuit designers, validation engineers, CAD managers, senior managers and executives to researchers and academicians from leading universities.

  • 2015 52nd ACM/EDAC/IEEE Design Automation Conference (DAC)

    The world's premier EDA and semiconductor design conference and exhibition. DAC features over 60 sessions on design methodologies and EDA tool developments, keynotes, panels, plus the NEW User Track presentations. A diverse worldwide community representing more than 1,000 organizations attends each year, from system designers and architects, logic and circuit designers, validation engineers, CAD managers, senior managers and executives to researchers and academicians from leading universities.

  • 2014 51st ACM/EDAC/IEEE Design Automation Conference (DAC)

    DAC Description for TMRF The world's premier EDA and semiconductor design conference and exhibition. DAC features over 60 sessions on design methodologies and EDA tool developments, keynotes, panels, plus the NEW User Track presentations. A diverse worldwide community representing more than 1,000 organizations attends each year, from system designers and architects, logic and circuit designers, validation engineers, CAD managers, senior managers and executives to researchers and academicians from leading

  • 2013 50th ACM/EDAC/IEEE Design Automation Conference (DAC)

    The world's premier EDA and semiconductor design conference and exhibition. DAC features over 60 session on design methodologies and EDA tool developments, keynotes, panels, plus User Track presentations. A diverse worldwide community representing more than 1,000 organization attends each year, from system designers and architects, logic and circuit designers, validation engineers, CAD managers, senior managers and executives to researchers and academicians from leading universities.

  • 2012 49th ACM/EDAC/IEEE Design Automation Conference (DAC)

    The Design Automation Conference (DAC) is the premier event for the design of electronic circuits and systems, and for EDA and silicon solutions. DAC features a wide array of technical presentations plus over 200 of the leading electronics design suppliers

  • 2011 48th ACM/EDAC/IEEE Design Automation Conference (DAC)

    The Design Automation Conference is the world s leading technical conference and tradeshow on electronic design and design automation. DAC is where the IC Design and EDA ecosystem learns, networks, and does business.

  • 2010 47th ACM/EDAC/IEEE Design Automation Conference (DAC)

    The Design Automation Conference (DAC) is the premier event for the design of electronic circuits and systems, and for EDA and silicon solutions. DAC features a wide array of technical presentations plus over 200 of the leading electronics design suppliers.

  • 2009 46th ACM/EDAC/IEEE Design Automation Conference (DAC)

    DAC is the premier event for the electronic design community. DAC offers the industry s most prestigious technical conference in combination with the biggest exhibition, bringing together design, design automation and manufacturing market influencers.

  • 2008 45th ACM/EDAC/IEEE Design Automation Conference (DAC)

    The Design Automation Conference (DAC) is the premier event for the design of electronic circuits and systems, and for EDA and silicon solutions. DAC features a wide array of technical presentations plus over 250 of the leading electronics design suppliers.

  • 2007 44th ACM/IEEE Design Automation Conference (DAC)

    The Design Automation Conference (DAC) is the premier Electronic Design Automation (EDA) and silicon solution event. DAC features over 50 technical sessions covering the latest in design methodologies and EDA tool developments and an Exhibition and Demo Suite area with over 250 of the leading EDA, silicon and IP Providers.

  • 2006 43rd ACM/IEEE Design Automation Conference (DAC)

  • 2005 42nd ACM/IEEE Design Automation Conference (DAC)

  • 2004 41st ACM/IEEE Design Automation Conference (DAC)

  • 2003 40th ACM/IEEE Design Automation Conference (DAC)

  • 2002 39th ACM/IEEE Design Automation Conference (DAC)

  • 2001 38th ACM/IEEE Design Automation Conference (DAC)

  • 2000 37th ACM/IEEE Design Automation Conference (DAC)

  • 1999 36th ACM/IEEE Design Automation Conference (DAC)

  • 1998 35th ACM/IEEE Design Automation Conference (DAC)

  • 1997 34th ACM/IEEE Design Automation Conference (DAC)

  • 1996 33rd ACM/IEEE Design Automation Conference (DAC)


2020 59th IEEE Conference on Decision and Control (CDC)

The CDC is the premier conference dedicated to the advancement of the theory and practice of systems and control. The CDC annually brings together an international community of researchers and practitioners in the field of automatic control to discuss new research results, perspectives on future developments, and innovative applications relevant to decision making, automatic control, and related areas.


2020 American Control Conference (ACC)

The ACC is the annual conference of the American Automatic Control Council (AACC, the U.S. national member organization of the International Federation for Automatic Control (IFAC)). The ACC is internationally recognized as a premier scientific and engineering conference dedicated to the advancement of control theory and practice. The ACC brings together an international community of researchers and practitioners to discuss the latest findings in automatic control. The 2020 ACC technical program will

  • 2019 American Control Conference (ACC)

    Technical topics include biological systems, vehicle dynamics and control, adaptive control, consensus control, cooperative control, control of communication networks, control of networked systems, control of distributed parameter systems, decentralized control, delay systems, discrete-event systems, fault detection, fault-tolerant systems, flexible structures, flight control, formation flying, fuzzy systems, hybrid systems, system identification, iterative learning control, model predictive control, linear parameter-varying systems, linear matrix inequalities, machine learning, manufacturing systems, robotics, multi-agent systems, neural networks, nonlinear control, observers, optimal control, optimization, path planning, navigation, robust control, sensor fusion, sliding mode control, stochastic systems, switched systems, uncertain systems, game theory.

  • 2018 Annual American Control Conference (ACC)

    Technical topics include biological systems, vehicle dynamics and control, adaptive control, consensus control, cooperative control, control of communication networks, control of networked systems, control of distributed parameter systems, decentralized control, delay systems, discrete-event systems, fault detection, fault-tolerant systems, flexible structures, flight control, formation flying, fuzzy systems, hybrid systems, system identification, iterative learning control, model predictive control, linear parameter-varying systems, linear matrix inequalities, machine learning, manufacturing systems, robotics, multi-agent systems, neural networks, nonlinear control, observers, optimal control, optimization, path planning, navigation, robust control, sensor fusion, sliding mode control, stochastic systems, switched systems, uncertain systems, game theory.

  • 2017 American Control Conference (ACC)

    Technical topics include biological systems, vehicle dynamics and control, adaptive control, consensus control, cooperative control, control of communication networks, control of networked systems, control of distributed parameter systems, decentralized control, delay systems, discrete-event systems, fault detection, fault-tolerant systems, flexible structures, flight control, formation flying, fuzzy systems, hybrid systems, system identification, iterative learning control, model predictive control, linear parameter-varying systems, linear matrix inequalities, machine learning, manufacturing systems, robotics, multi-agent systems, neural networks, nonlinear control, observers, optimal control, optimization, path planning, navigation, robust control, sensor fusion, sliding mode control, stochastic systems, switched systems, uncertain systems, game theory.

  • 2016 American Control Conference (ACC)

    Control systems theory and practice. Conference topics include biological systems, vehicle dynamics and control, consensus control, cooperative control, control of communication networks, control of networked systems, control of distributed parameter systems, decentralized control, delay systems, discrete-event systems, fault detection, fault-tolerant systems, flexible structures, flight control, formation flying, fuzzy systems, hybrid systems, system identification, iterative learning control, model predictive control, linear parameter-varying systems, linear matrix inequalities, machine learning, manufacturing systems, robotics, multi-agent systems, neural networks, nonlinear control, observers, optimal control, optimization, path planning, navigation, robust control, sensor fusion, sliding mode control, stochastic systems, switched systems, uncertain systems, game theory.

  • 2015 American Control Conference (ACC)

    control theory, technology, and practice

  • 2014 American Control Conference - ACC 2014

    All areas of the theory and practice of automatic control, including but not limited to network control systems, model predictive control, systems analysis in biology and medicine, hybrid and switched systems, aerospace systems, power and energy systems and control of nano- and micro-systems.

  • 2013 American Control Conference (ACC)

    Control systems theory and practice. Conference themes on sustainability, societal challenges for control, smart healthcare systems. Conference topics include biological systems, vehicle dynamics and control, consensus control, cooperative control, control of communication networks, control of networked systems, control of distributed parameter systems, decentralized control, delay systems, discrete-event systems, fault detection, fault-tolerant systems, flexible structures, flight control, formation flying, fuzzy systems, hybrid systems, system identification, iterative learning control, model predictive control, linear parameter-varying systems, linear matrix inequalities, machine learning, manufacturing systems, robotics, multi-agent systems, neural networks, nonlinear control, observers, optimal control, optimization, path planning, navigation, robust control, sensor fusion, sliding mode control, stochastic systems, switched systems, uncertain systems, game theory.

  • 2012 American Control Conference - ACC 2012

    All areas of control engineering and science.

  • 2011 American Control Conference - ACC 2011

    ACC provides a forum for bringing industry and academia together to discuss the latest developments in the area of Automatic Control Systems, from new control theories, to the advances in sensors and actuator technologies, and to new applications areas for automation.

  • 2010 American Control Conference - ACC 2010

    Theory and practice of automatic control

  • 2009 American Control Conference - ACC 2009

    The 2009 ACC technical program will cover new developments related to theory, application, and education in control science and engineering. In addition to regular technical sessions the program will also feature interactive and tutorial sessions and preconference workshops.

  • 2008 American Control Conference - ACC 2008

  • 2007 American Control Conference - ACC 2007

  • 2006 American Control Conference - ACC 2006 (Silver Anniversary)

  • 2005 American Control Conference - ACC 2005

  • 2004 American Control Conference - ACC 2004

  • 2003 American Control Conference - ACC 2003

  • 2002 American Control Conference - ACC 2002

  • 2001 American Control Conference - ACC 2001

  • 2000 American Control Conference - ACC 2000

  • 1999 American Control Conference - ACC '99

  • 1998 American Control Conference - ACC '98

  • 1997 American Control Conference - ACC '97

  • 1996 13th Triennial World Congress of the International Federation of Automatic Control (IFAC)


2020 IEEE 29th International Symposium on Industrial Electronics (ISIE)

ISIE focuses on advancements in knowledge, new methods, and technologies relevant to industrial electronics, along with their applications and future developments.


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Periodicals related to Biochemical analysis

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Automatic Control, IEEE Transactions on

The theory, design and application of Control Systems. It shall encompass components, and the integration of these components, as are necessary for the construction of such systems. The word `systems' as used herein shall be interpreted to include physical, biological, organizational and other entities and combinations thereof, which can be represented through a mathematical symbolism. The Field of Interest: shall ...


Automation Science and Engineering, IEEE Transactions on

The IEEE Transactions on Automation Sciences and Engineering (T-ASE) publishes fundamental papers on Automation, emphasizing scientific results that advance efficiency, quality, productivity, and reliability. T-ASE encourages interdisciplinary approaches from computer science, control systems, electrical engineering, mathematics, mechanical engineering, operations research, and other fields. We welcome results relevant to industries such as agriculture, biotechnology, healthcare, home automation, maintenance, manufacturing, pharmaceuticals, retail, ...


Biomedical Circuits and Systems, IEEE Transactions on

The Transactions on Biomedical Circuits and Systems addresses areas at the crossroads of Circuits and Systems and Life Sciences. The main emphasis is on microelectronic issues in a wide range of applications found in life sciences, physical sciences and engineering. The primary goal of the journal is to bridge the unique scientific and technical activities of the Circuits and Systems ...


Biomedical Engineering, IEEE Reviews in

The IEEE Reviews in Biomedical Engineering will review the state-of-the-art and trends in the emerging field of biomedical engineering. This includes scholarly works, ranging from historic and modern development in biomedical engineering to the life sciences and medicine enabled by technologies covered by the various IEEE societies.


Biomedical Engineering, IEEE Transactions on

Broad coverage of concepts and methods of the physical and engineering sciences applied in biology and medicine, ranging from formalized mathematical theory through experimental science and technological development to practical clinical applications.


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Most published Xplore authors for Biochemical analysis

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Xplore Articles related to Biochemical analysis

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The use of micro-optics for miniaturized chemical and biomedical analysis systems

2000 IEEE/LEOS International Conference on Optical MEMS (Cat. No.00EX399), 2000

A brief overview of optics in biochemistry is presented, followed by an examination of published works on the integration of micro-optics and miniaturized biochemical systems. We will also give recent results from our own efforts.


Microfabricated separator and manipulator of blood cells for health care devices

Digest of Papers Microprocesses and Nanotechnology 2000. 2000 International Microprocesses and Nanotechnology Conference (IEEE Cat. No.00EX387), 2000

A microfabricated capillary electrophoresis chip has been recently developed and many researchers have reported its attractive potentials such as the drastic increase of speed, reduced sample volumes, higher resolutions and so forth. Furthermore the more aggressive strategy is to integrate a variety of components of analysis system on a chip and has been rapidly developed as so- called "/spl mu/-TAS ...


Application of statistical and neural network techniques to biochemical data analysis

Proceedings of the 1997 American Control Conference (Cat. No.97CH36041), 1997

The methods of self-organising map (SOM) and principal components analysis (PCA) are investigated for analysing biochemical data generated in screening programmes to discover new pharmaceutically active compounds in microbial extracts. The organisms investigated, which belonged to the genus Streptomyces, had previously been classified by numerical taxonomy using a probabilistic identification matrix to one of 23 major taxonomic clusters based on ...


Automatic Extraction of Kinetic Information from Biochemical Literatures

2009 Sixth International Conference on Fuzzy Systems and Knowledge Discovery, 2009

Software for computational analysis and simulation of biochemical systems has become one of the major computational tools in systems biology in recent years. Most of them use parameterized differential equations to model and describe biochemical systems. Although biochemical principles, such as enzyme mechanics, have been developed to derive kinetic rate equations, measuring and providing parameters in the equations are expensive ...


The electromagnetic fields radiated from a monolithic spiral coil acoustic transduction sensor

2009 IEEE International Ultrasonics Symposium, 2009

The monolithic spiral coil acoustic transduction (MSCAT) sensor platform is a novel bulk acoustic wave (BAW) device which is excited by a gold spiral coil antenna photolithographically deposited on one side of an AT-quartz wafer. The MSCAT platform can operate at very high frequencies by efficiently exciting high harmonic transverse shear modes (TSMs) with the application of a high frequency ...


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Educational Resources on Biochemical analysis

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IEEE.tv Videos

IMS 2012 Microapps - Improve Microwave Circuit Design Flow Through Passive Model Yield and Sensitivity Analysis
IMS 2011 Microapps - Yield Analysis During EM Simulation
IMS 2011 Microapps - A Practical Approach to Verifying RFICs with Fast Mismatch Analysis
IMS MicroApps: Multi-Rate Harmonic Balance Analysis
Spectrum Analysis: RF Boot Camp
Surgical Robotics: Analysis and Control Architecture for Semiautonomous Robotic Surgery
IMS 2012 Microapps - Generation and Analysis Techniques for Cost-efficient SATCOM Measurements Richard Overdorf, Agilent
New Approach of Vehicle Electrification: Analysis of Performance and Implementation Issue
A Flexible Testbed for 5G Waveform Generation and Analysis: MicroApps 2015 - Keysight Technologies
Similarity and Fuzzy Logic in Cluster Analysis
IMS 2011 Microapps - STAN Tool: A New Method for Linear and Nonlinear Stability Analysis of Microwave Circuits
IMS 2011 Microapps - Remcom's XFdtd and Wireless InSite: Advanced Tools for Advanced Communication Systems Analysis
IMS 2011 Microapps - Tools for Creating FET and MMIC Thermal Profiles
Zohara Cohen AMA EMBS Individualized Health
Network Analysis: RF Boot Camp
Micro-Apps 2013: Power Added Efficiency (PAE) Analysis with 8990B Peak Power Analyzer
Brooklyn 5G Summit 2014: Dr. Robert Heath on Coverage and Capacity Analysis of Dense Millimeter Wave Cellular System
Developing Automated Analysis Tools for Space/Time Sidechannel Detection - IEEE SecDev 2016
Real-time Spectrogram Analysis of Continuous Optical Wavefields - José Azaña - Closing Ceremony, IPC 2018
Robotics History: Narratives and Networks Oral Histories: Barbara Hayes Roth

IEEE-USA E-Books

  • The use of micro-optics for miniaturized chemical and biomedical analysis systems

    A brief overview of optics in biochemistry is presented, followed by an examination of published works on the integration of micro-optics and miniaturized biochemical systems. We will also give recent results from our own efforts.

  • Microfabricated separator and manipulator of blood cells for health care devices

    A microfabricated capillary electrophoresis chip has been recently developed and many researchers have reported its attractive potentials such as the drastic increase of speed, reduced sample volumes, higher resolutions and so forth. Furthermore the more aggressive strategy is to integrate a variety of components of analysis system on a chip and has been rapidly developed as so- called "/spl mu/-TAS (micro total analysis system)", which is composed of microchannel network for sample pre- and post treatment, chemical reactions and separations and also detection systems like bio/chemical sensors, microoptics and microelectronic devices. In order to achieve the health care device that allows short-time inspection of human body by analyzing a slight amount of body fluid like blood, urine or saliva, we have been developing the micro analysis devices, and so far on-chip analysis of blood cells and serum have been studied based on micro-capillary electrophoresis chips. In this article, for the purpose of on-chip cell and/or particle separation and manipulation, (1) a separation of the serum and blood cells from the whole blood using a centrifugal chip, and (2) cell trapping using interdigitated electrodes have been investigated.

  • Application of statistical and neural network techniques to biochemical data analysis

    The methods of self-organising map (SOM) and principal components analysis (PCA) are investigated for analysing biochemical data generated in screening programmes to discover new pharmaceutically active compounds in microbial extracts. The organisms investigated, which belonged to the genus Streptomyces, had previously been classified by numerical taxonomy using a probabilistic identification matrix to one of 23 major taxonomic clusters based on 41 biological characters. The data related to extracts of organisms from 3 major clusters were available from 8 different pharmaceutical screens. When analysed by both techniques the data clustered into 3 groups which fitted well with their original taxonomic grouping. The results indicate the power of the techniques in analysing biological data and the predictive potential it may offer natural product screening programmes in the pharmaceutical industry.

  • Automatic Extraction of Kinetic Information from Biochemical Literatures

    Software for computational analysis and simulation of biochemical systems has become one of the major computational tools in systems biology in recent years. Most of them use parameterized differential equations to model and describe biochemical systems. Although biochemical principles, such as enzyme mechanics, have been developed to derive kinetic rate equations, measuring and providing parameters in the equations are expensive and laborious. Observe that many kinetic parameters have been experimentally measured in previous research, and recorded in published literatures. Instead of measuring kinetic parameters from experiments, one of the alternatives is to find parameters from literatures. However, the amount of such literatures is huge, and reading them is very time-consuming. About the previous research of kinetic parameters are focused on literature including kinetic parameters or not. In this paper, we present a software tool (KIND) for automatic extraction of kinetic parameters from full-length literatures. In order to help biologist easy to retrieve kinetic parameters information, KIND can automatic generate table format to present kinetic parameters information from literatures. We aim at developing a tool that can be used to compile a database of kinetic parameters from literatures to aid the modeling of biological processes.

  • The electromagnetic fields radiated from a monolithic spiral coil acoustic transduction sensor

    The monolithic spiral coil acoustic transduction (MSCAT) sensor platform is a novel bulk acoustic wave (BAW) device which is excited by a gold spiral coil antenna photolithographically deposited on one side of an AT-quartz wafer. The MSCAT platform can operate at very high frequencies by efficiently exciting high harmonic transverse shear modes (TSMs) with the application of a high frequency RF signal to the spiral coil. Since one surface of the MSCAT device is bare, this device can be used as a sensing platform upon which one deposits analyte selective chemical or biological films. The bare surface allows the detection of analyte induced mechanical (mass and viscoelasticity) and electrical (conductivity and dielectric constant) property changes in the film. Although previous work has shown that the MSCAT sensor is a highly sensitive sensor platform for chemical and biological analyte detection, the form of the electric field in the AT-quartz substrate is not well understood. In this work finite element analysis (FEA) was used to obtain the electromagnetic fields radiated by the spiral coil antenna deposited on AT-cut quartz. The theoretical results were compared to experimental measurements for specific spiral coil geometries. The spiral coil antenna was shown to produce electric fields that have components in both the lateral and thickness directions. These fields were responsible for exciting the TSM in the MSCAT sensor platform. Further, it was also shown that liquid properties on the sensor surface significantly alter the form of the radiated electric field. Also, the relative magnitude of the electric field in the AT-cut quartz vary significantly dependent on operating frequency and the spiral coil geometry.

  • Determination of Four Volatile Halohydrocarbons in Water by Purge and Trap-Gas Chromatography-Mass

    A sensitive and fast analytical method using purge-and-trap (P&T) on-line coupling with gas chromatography was developed for the determination of four trace volatile halohydrocarbons including methylene, chloroform, carbon tetrachloride and trichloroethylene in water. The analytes were purged for 10min from the sample by high purity nitrogen and preconcentrated in the cooled trap at -80 degC . The halohydrocarbons were separated with an gas chromatograph by a suitable temperature program and detected by means of a mass spectrometer using selected ion monitoring (SIM). The detection limits were found to be in the range of 0.0008 to 0.02mug/L, the relative deviations ranged from 1.9% to 5.4%, the recovery ratios ranged were 89% to 104%, The linearity ranges of 4 compounds were in the range of 0.001 to 50mug/L, with correlation coefficients from 0.9991 to 0.9997. The method is fast, sensitive, simple. It has better accuracy and precision in determination of these halohydrocarbons in water compared with the traditional method.

  • Disease gene-fishing in molecular interaction networks: A case study in colorectal cancer

    In the post-genome era, disease-relevant gene finding and prioritization have focused on genome-wide association studies and molecular interaction networks, due to their power in characterizing the functions of genes/proteins in genomics and network biology contexts. In this paper, we describe a simple yet generic computational framework based on protein interaction networks to perform and evaluate disease gene-hunting, using colorectal cancer as a case study. We applied statistical measurements including specificity, sensitivity and Positive Predictive Value (PPV) to evaluate the performance of disease gene ranking methods, which we broke down into seed gene selection, protein interaction data quality and coverage, and network-based gene-ranking strategies. We discovered that best results may be obtained by using curated gene sets as seeds, applying protein interaction data set with high data coverage and decent quality, and adopting variants of local degree methods.

  • Heuristic neuro-fuzzy model for evaluation of urban transportation projects

    Summary form only given. Urban transportation planning projects are largely concerned with providing two benefits: trip time reduction and operating cost reduction. However, neglect of human factors in transportation projects and failure to recognise urban transportation as a basic need of a society, have resulted in systems that do not execute their primary objective: to move human beings quickly, comfortably, economically and effectively. The work described here develops a methodology to evaluate urban transportation systems based on qualitative descriptions, wherein humans and their environment are the main factors. The method is based on a neuro-fuzzy approach with heuristic rules organised in a hierarchy designed for a participatory environment of experts, current users and future users. All inputs are transformed into linguistic variables by ascribing degrees of belief to arrive at a final conclusion to assign a humanistic grade to the overall analysis. Neuro-fuzzy technology has been chosen because of its ability to mimic human decision-making and because of the ease of model-validation.

  • The role of shape analysis in drug design

    In drug design the analysis of the shapes of three-dimensional molecular bodies, as opposed to the more conventional study of the molecular skeletons of formal bond systems, approach to modeling biochemical interactions. A family of computer techniques is described that are aimed at a nonvisual, numerical characterization and classification of molecular shapes and take into account the conformational nonrigidity of drug molecules. Novel developments include the shape characterization of conformationally flexible molecules, using the dynamic shape code technique.<<ETX>>

  • A single cell multi-analysis system for electrophysiological studies

    A micro analysis system for multi-purpose electrophysiological studies of single cells has been designed, fabricated, and characterized. The micro electrophysiological analysis system (/spl mu/-EPAS) contains multiple extracellular opposing electrode pairs that interface with a single cell inside an analysis cavity. These electrodes can be used for general single electrode extracellular stimulation/recording studies, dual electrode applications such as impedance spectroscopy, and for applications requiring a greater number of electrodes such as impedance tomography. Additionally, the analysis system contains a sealing/clamping mechanism and a backside extracellular reference electrode for patch clamping studies. The analysis cavities were designed in an array format for parallel analyses. Bovine chromaffin cells were used as a target to demonstrate and characterize the system. Using the integrated glass sealing ring, giga-seals were obtained on a population of chromaffin cells. The micro system generated maximum giga-seal resistances of 1.2G/spl Omega/ with non-sealed average cavity-to-backside resistances of 0.5M/spl Omega/. Furthermore, the cellular analysis system was demonstrated for electrical impedance spectroscopy on chromaffin cells over a range from 40.0 Hz to 1.0 MHz.



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