Microfluidics

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Microfluidics deals with the behavior, precise control and manipulation of fluids that are geometrically constrained to a small, typically sub-millimeter, scale. (Wikipedia.org)






Conferences related to Microfluidics

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2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)

The conference program will consist of plenary lectures, symposia, workshops and invitedsessions of the latest significant findings and developments in all the major fields of biomedical engineering.Submitted papers will be peer reviewed. Accepted high quality papers will be presented in oral and postersessions, will appear in the Conference Proceedings and will be indexed in PubMed/MEDLINE


2020 IEEE 70th Electronic Components and Technology Conference (ECTC)

ECTC is the premier international conference sponsored by the IEEE Components, Packaging and Manufacturing Society. ECTC paper comprise a wide spectrum of topics, including 3D packaging, electronic components, materials, assembly, interconnections, device and system packaging, optoelectronics, reliability, and simulation.


2020 IEEE Frontiers in Education Conference (FIE)

The Frontiers in Education (FIE) Conference is a major international conference focusing on educational innovations and research in engineering and computing education. FIE 2019 continues a long tradition of disseminating results in engineering and computing education. It is an ideal forum for sharing ideas, learning about developments and interacting with colleagues inthese fields.


2020 IEEE International Instrumentation and Measurement Technology Conference (I2MTC)

The Conference focuses on all aspects of instrumentation and measurement science andtechnology research development and applications. The list of program topics includes but isnot limited to: Measurement Science & Education, Measurement Systems, Measurement DataAcquisition, Measurements of Physical Quantities, and Measurement Applications.


2020 Optical Fiber Communications Conference and Exhibition (OFC)

The Optical Fiber Communication Conference and Exhibition (OFC) is the largest global conference and exhibition for optical communications and networking professionals. For over 40 years, OFC has drawn attendees from all corners of the globe to meet and greet, teach and learn, make connections and move business forward.OFC attracts the biggest names in the field, offers key networking and partnering opportunities, and provides insights and inspiration on the major trends and technology advances affecting the industry. From technical presentations to the latest market trends and predictions, OFC is a one-stop-shop.


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Periodicals related to Microfluidics

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Antennas and Propagation, IEEE Transactions on

Experimental and theoretical advances in antennas including design and development, and in the propagation of electromagnetic waves including scattering, diffraction and interaction with continuous media; and applications pertinent to antennas and propagation, such as remote sensing, applied optics, and millimeter and submillimeter wave techniques.


Biomedical Circuits and Systems, IEEE Transactions on

The Transactions on Biomedical Circuits and Systems addresses areas at the crossroads of Circuits and Systems and Life Sciences. The main emphasis is on microelectronic issues in a wide range of applications found in life sciences, physical sciences and engineering. The primary goal of the journal is to bridge the unique scientific and technical activities of the Circuits and Systems ...


Biomedical Engineering, IEEE Reviews in

The IEEE Reviews in Biomedical Engineering will review the state-of-the-art and trends in the emerging field of biomedical engineering. This includes scholarly works, ranging from historic and modern development in biomedical engineering to the life sciences and medicine enabled by technologies covered by the various IEEE societies.


Biomedical Engineering, IEEE Transactions on

Broad coverage of concepts and methods of the physical and engineering sciences applied in biology and medicine, ranging from formalized mathematical theory through experimental science and technological development to practical clinical applications.


Computer-Aided Design of Integrated Circuits and Systems, IEEE Transactions on

Methods, algorithms, and human-machine interfaces for physical and logical design, including: planning, synthesis, partitioning, modeling, simulation, layout, verification, testing, and documentation of integrated-circuit and systems designs of all complexities. Practical applications of aids resulting in producible analog, digital, optical, or microwave integrated circuits are emphasized.


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Most published Xplore authors for Microfluidics

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Xplore Articles related to Microfluidics

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Integrated Digital and Analog Microfluidics by EWOD and LDEP

2006 1st IEEE International Conference on Nano/Micro Engineered and Molecular Systems, 2006

EWOD (electrowetting-on-dielectric) and LDEP (liquid dielectrophoresis) are investigated to provide digital and analog microfluidic functions on an integrated chip respectively. By altering the frequency of the applied voltage and the surrounding medium of a EWOD device, we found that when using oil as surrounding medium and applying an AC signal 100 kHz, liquid column would be drawn and follow the ...


Fabrication Method for Paper Microfluidics Utilizing 3D Printing and PDMS Stamps

2016 32nd Southern Biomedical Engineering Conference (SBEC), 2016

Paper microfluidics is an emerging technology that offers a simple and inexpensive alternative to traditional microfluidics. Paper is an attractive medium for microfluidic devices because of its inherent hydrophilicity and low cost. Hydrophobic materials including wax and photoresist are used to pattern the paper. The most common method for making paper microfluidic analytical devices (μPAD) is wax printing, however, this ...


Autonomous capillary microfluidics for rapid nanoreceptor assembly and biosensing

2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), 2015

We report an autonomous integrated microsystem comprising capillary microfluidics and impedimetric sensors for rapid nanoprobe assembly and antibody detection. Using open-channel microfluidics, Tobacco mosaic virus- like particles (VLPs) are autonomously delivered on the impedance sensor, forming a dense functional sensing layer due to enhanced surface evaporation- assisted assembly. The process utilizes 5μL of VLP solution (0.2mg/mL) and requires 6 minutes ...


Three-dimensional digital microfluidics using an alternative current electrowetting-on-dielectric (AC-EWOD)

2013 Transducers & Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII), 2013

This paper describes three-dimensional (3D) digital microfluidics based on an alternative current electrowetting-on-dielectric (AC-EWOD) principle. To achieve the 3D manipulation of a droplet in two parallel plates, the dynamic behaviors of a water droplet actuated by AC-EWOD in various conditions are investigated by using high speed images. From the investigation, the optimum experimental conditions such as the applied frequency, switching ...


Low cost design and fabrication of PDMS microfluidics micromixers for DNA extraction

2017 IEEE Regional Symposium on Micro and Nanoelectronics (RSM), 2017

Efficient micromixing is required for fast reaction and improved mixing performance for DNA extraction in microfluidic devices. This study outlines a simple, low cost approach for prototyping design and fabrication of PDMS microfluidics micromixers for DNA extraction. The design is plotted using AutoCAD software and the master template is fabricated using a negative photoresist, SU-8, on a microscopic glass slide. ...


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Educational Resources on Microfluidics

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IEEE-USA E-Books

  • Integrated Digital and Analog Microfluidics by EWOD and LDEP

    EWOD (electrowetting-on-dielectric) and LDEP (liquid dielectrophoresis) are investigated to provide digital and analog microfluidic functions on an integrated chip respectively. By altering the frequency of the applied voltage and the surrounding medium of a EWOD device, we found that when using oil as surrounding medium and applying an AC signal 100 kHz, liquid column would be drawn and follow the thin connecting lines of the EWOD driving electrodes instead of remaining on top of the center of the EWOD driving electrodes. This new phenomenon is described in this paper and is regarded as a LDEP effect. Three fundamental tools for integrated digital and analog microfluidics are developed, including a digital-to-analog converter, an analog-to-digital converter, and a valve. Combining EWOD and LDEP effects, liquids can be pumped on a virtual channel (analog microfluidics), defined by energized thin LDEP electrode lines, continuously from liquid reservoir or from a digitized droplet (digital microfluidics). On the contrary, liquids on LDEP electrodes (analog microfluidics) can also be pumped on a EWOD electrode and be digitized in droplet forms with precise volumes (digital microfluidics). EWOD and LDEP can be selectively programmed on a single chip, making integrated digital and analog microfluidics a reality

  • Fabrication Method for Paper Microfluidics Utilizing 3D Printing and PDMS Stamps

    Paper microfluidics is an emerging technology that offers a simple and inexpensive alternative to traditional microfluidics. Paper is an attractive medium for microfluidic devices because of its inherent hydrophilicity and low cost. Hydrophobic materials including wax and photoresist are used to pattern the paper. The most common method for making paper microfluidic analytical devices (μPAD) is wax printing, however, this method requires an expensive and specialized printer that is limited to printing documents and channel designs. Our method uses inexpensive materials and tools accessible to most research labs in the US. We utilize 3D printers, a common tool available in many universities because of their versatility. Poly(dimethylsiloxane) (PDMS) wax stamps are used to deposit wax onto paper, forming microfluidic channels. The PDMS stamps are produced with ABS 3D printed molds designed in CAD software. A PDMS stamp is dipped into melted wax and then pressed onto paper much like the process of using a rubber stamp and ink. Once the wax is deposited, the paper is heated, letting the wax penetrate the paper and form hydrophilic channels. This rapid and simple procedure allows researchers to easily produce μPADs with the flexibility of CAD software and 3D printers.

  • Autonomous capillary microfluidics for rapid nanoreceptor assembly and biosensing

    We report an autonomous integrated microsystem comprising capillary microfluidics and impedimetric sensors for rapid nanoprobe assembly and antibody detection. Using open-channel microfluidics, Tobacco mosaic virus- like particles (VLPs) are autonomously delivered on the impedance sensor, forming a dense functional sensing layer due to enhanced surface evaporation- assisted assembly. The process utilizes 5μL of VLP solution (0.2mg/mL) and requires 6 minutes at room temperature compared to 3 hours in static environments. The functionalized impedance sensor is able to detect the presence of 1.2μg/mL target antibody within 10 minutes after functionalization. These results highlight the significant potential of the integrated system for rapid transducer functionalization and biosensing.

  • Three-dimensional digital microfluidics using an alternative current electrowetting-on-dielectric (AC-EWOD)

    This paper describes three-dimensional (3D) digital microfluidics based on an alternative current electrowetting-on-dielectric (AC-EWOD) principle. To achieve the 3D manipulation of a droplet in two parallel plates, the dynamic behaviors of a water droplet actuated by AC-EWOD in various conditions are investigated by using high speed images. From the investigation, the optimum experimental conditions such as the applied frequency, switching time, and gap between the top and bottom plates are obtained. As the concept proof, the 3D manipulation of a droplet is finally achieved by the combination of horizontal and vertical AC-EWOD actuation, providing us more space for digital microfluidics.

  • Low cost design and fabrication of PDMS microfluidics micromixers for DNA extraction

    Efficient micromixing is required for fast reaction and improved mixing performance for DNA extraction in microfluidic devices. This study outlines a simple, low cost approach for prototyping design and fabrication of PDMS microfluidics micromixers for DNA extraction. The design is plotted using AutoCAD software and the master template is fabricated using a negative photoresist, SU-8, on a microscopic glass slide. PDMS was used for replication of microfluidics channels to create a microfluidics chip due to its biocompatibility as well as other advantages pertaining to high performance of fluid delivery and biochemical reactions. High power microscopy (HPM) results show successful, insignificant difference in size, <;70 μm between the dimensions in the original design on AutoCAD software and the dimensions in PDMS microfluidics after fabrication. FTIR spectra shows peaks between 690 cm-1-1500 cm-1, indicating presence of DNA fragments from the fraction sample pooled at microfluidics outlet, which signifies successful DNA extraction.

  • MEMS-based flow cytometry: microfluidics-based cell identification system by fluorescent imaging

    This study utilizes MEMS technology to realize a novel low-cost microfluidics- based biochip system for flow-type cell handling. Powered by vacuum pump, the microfluidic driving system enables cells to move in order one by one in the biochip by an effect of sheath flow prefocus. Then, cells are guided to a fluorescent inspection region where two detection tasks such as cell image identification and cell counting are conducted. Currently, the glass-based biochip has been manufactured and all the related devices have been well set up in our laboratory. With this proposed prototype system, typical results about cell separation of yeast cell and PC-3 cell are available and their separated images are also presented, respectively.

  • Finger-powered droplet actuation by electrophoretic force for portable microfluidics

    We report finger-powered digital microfluidics based on electrophoretic control of droplets (EPD). An array of piezoelectric elements is connected to electrodes immersed in a dielectric fluid and deflected to charge and transport an aqueous droplet between adjacent electrodes. Using this scheme, we successfully demonstrated the transport and merging of aqueous droplets. Further, we confirmed direct manipulation of droplets of body fluids, such as human saliva, using our finger-powered EPD.

  • Design, Simulation and Fabrication of Electrowetting-Based Actuators for Integrated Digital Microfluidics

    Electrowetting-on-dielectric (EWOD) is a promising method for manipulating tiny amounts of liquids. However, the miniaturization and the monolithic integration become the great challenges to improve the EWOD applications in actual lab-on-a-chip systems. In this paper, we present an IC-compatible digital microfluidic actuator, which uses silicon as the substrate and the thermally grown SiO<sub>2</sub> film on heavily phosphorus-doped poly-silicon microelectrodes as the high quality dielectric layer. The fundamental EWOD operations, such as the droplet transportation, division, creation, and mergence, are numerically analyzed by using the computational fluidic software, CFD-ACE+. The simulation results of transportation and division show that it is an antinomy to select the gap height between two plates for improving respective performances. A tradeoff value of the gap height of 133 mum is ultimately used to implement the fundamental operations with one actuator. In experiments, all above operations are successfully achieved in air by applying 70 V voltages. Owing to the IC-compatible fabrication, the integration with peripheral circuits is technically feasible to achieve a miniaturized microfluidics

  • Work in progress — Influences of student experiential background in a problem-based multidisciplinary microfluidics laboratory course

    This paper will focus on student experiences in a multidisciplinary microfluidics laboratory course and how these related to students' course expectations, prior experiences and collaboration in laboratory groups as well as other factors. The course under discussion, initially developed at the University of Cincinnati, is a laboratory course that introduces undergraduate and graduate students to microfluidic device development. A unique aspect of the course, which is comprised of modeling, fabrication, and analysis of SU-8 micromixers, is the focus on an extended problem-based learning example that underlies all course activities. This course is an application in microfluidics, a multidisciplinary field that deals with the behavior and precise control of microliter and nanoliter volumes. The course is currently being expanded to four other universities with the assistance of an NSF CCLI Phase II grant (DUE-0814911). The dissemination at several sites allows the opportunity to examine the effects of differing student backgrounds on their experience with and reactions to the course structure and make recommendations to the project team regarding future pedagogical modifications that should be made to improve student learning and interest in pursuing microfluidics.

  • 3D Droplet Actuation in Digital Microfluidics Devices

    We introduce a method for 3D droplet actuation in digital microfluidics, which we have called all terrain droplet actuation (ATDA), in which droplets are manipulated on inclined, declined, vertical, twisted and upside down architectures. ATDA enables discrete processes on a single platform without thermal, chemical, or biological interference between them. To illustrate this capacity, we developed sensors capable of cycling droplets between distinct temperatures and oxygen milieu. We anticipate that ATDA will have significant impact in the field of microfluidics and the growing trend toward laboratory miniaturization.



Standards related to Microfluidics

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