652 resources related to Cerebrospinal Fluid
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The conference program will consist of plenary lectures, symposia, workshops and invitedsessions of the latest significant findings and developments in all the major fields of biomedical engineering.Submitted papers will be peer reviewed. Accepted high quality papers will be presented in oral and postersessions, will appear in the Conference Proceedings and will be indexed in PubMed/MEDLINE
The CDC is the premier conference dedicated to the advancement of the theory and practice of systems and control. The CDC annually brings together an international community of researchers and practitioners in the field of automatic control to discuss new research results, perspectives on future developments, and innovative applications relevant to decision making, automatic control, and related areas.
2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI 2020)
The IEEE International Symposium on Biomedical Imaging (ISBI) is the premier forum for the presentation of technological advances in theoretical and applied biomedical imaging. ISBI 2020 will be the 17th meeting in this series. The previous meetings have played a leading role in facilitating interaction between researchers in medical and biological imaging. The 2020 meeting will continue this tradition of fostering cross-fertilization among different imaging communities and contributing to an integrative approach to biomedical imaging across all scales of observation.
ECTC is the premier international conference sponsored by the IEEE Components, Packaging and Manufacturing Society. ECTC paper comprise a wide spectrum of topics, including 3D packaging, electronic components, materials, assembly, interconnections, device and system packaging, optoelectronics, reliability, and simulation.
The 2020 IEEE International Conference on Systems, Man, and Cybernetics (SMC 2020) will be held in Metro Toronto Convention Centre (MTCC), Toronto, Ontario, Canada. SMC 2020 is the flagship conference of the IEEE Systems, Man, and Cybernetics Society. It provides an international forum for researchers and practitioners to report most recent innovations and developments, summarize state-of-the-art, and exchange ideas and advances in all aspects of systems science and engineering, human machine systems, and cybernetics. Advances in these fields have increasing importance in the creation of intelligent environments involving technologies interacting with humans to provide an enriching experience and thereby improve quality of life. Papers related to the conference theme are solicited, including theories, methodologies, and emerging applications. Contributions to theory and practice, including but not limited to the following technical areas, are invited.
IEEE Antennas and Wireless Propagation Letters (AWP Letters) will be devoted to the rapid electronic publication of short manuscripts in the technical areas of Antennas and Wireless Propagation.
The theory, design and application of Control Systems. It shall encompass components, and the integration of these components, as are necessary for the construction of such systems. The word `systems' as used herein shall be interpreted to include physical, biological, organizational and other entities and combinations thereof, which can be represented through a mathematical symbolism. The Field of Interest: shall ...
The Transactions on Biomedical Circuits and Systems addresses areas at the crossroads of Circuits and Systems and Life Sciences. The main emphasis is on microelectronic issues in a wide range of applications found in life sciences, physical sciences and engineering. The primary goal of the journal is to bridge the unique scientific and technical activities of the Circuits and Systems ...
The IEEE Reviews in Biomedical Engineering will review the state-of-the-art and trends in the emerging field of biomedical engineering. This includes scholarly works, ranging from historic and modern development in biomedical engineering to the life sciences and medicine enabled by technologies covered by the various IEEE societies.
Broad coverage of concepts and methods of the physical and engineering sciences applied in biology and medicine, ranging from formalized mathematical theory through experimental science and technological development to practical clinical applications.
2011 International Conference on Remote Sensing, Environment and Transportation Engineering, 2011
Objective: We study on the transmigration ingredient in cerebrospinal fluid with SiNiSan Freeze-dry Powder in order to provide dependable evidence about determining that Sini San can enhance the sleep function with drug effect material base. Method: We use HPLC method, the gradient elution, and determine the transmigration ingredient of cerebrospinal fluid in Sini San Freeze-dry Powder.The chromatograph condition: Hypersil C18 ...
The 3rd International Winter Conference on Brain-Computer Interface, 2015
The disturbance in cerebrospinal fluid (CSF) circulation is believed to be one of the main causes of hydrocephalus and its variants. Resistance to CSF outflow (Rout) is a parameter, which indicates the degree of CSF disturbance. I is used as supplementary parameter in diagnosing NPH and is calculated by CSF infusion test. During the infusion test, the gradual increase in ...
The 6th 2013 Biomedical Engineering International Conference, 2013
A novel technique to analyze propagation of fluid flow pattern based on magnetic resonance (MR) velocimetry has been developed and applied to cerebrospinal fluid (CSF) dynamics in intracranial space. This technique evaluates spatial distribution of the correlation time as well as correlation coefficient of velocity waveform with respect to an arbitrary reference waveform using quantitative velocity imaging with phase contrast ...
2016 Eighth International Conference on Measuring Technology and Mechatronics Automation (ICMTMA), 2016
Biomechanically, one of the important roles of the cerebrospinal fluid playing is to provide effective damping against sudden intracranial brain motion during head impact. Thus, the mesh density of cerebrospinal fluid in finite element model needs to be studied because of its significant impact on the brain's biomechanical responses, such as relative displacement. This study based on a previous finite ...
IEEE Transactions on Biomedical Engineering, 2007
Advances in magnetic resonance (MR) imaging techniques enable the accurate measurements of cerebrospinal fluid (CSF) flow in the human brain. In addition, image reconstruction tools facilitate the collection of patient- specific brain geometry data such as the exact dimensions of the ventricular and subarachnoidal spaces (SAS) as well as the computer-aided reconstruction of the CSF-filled spaces. The solution of the ...
Objective: We study on the transmigration ingredient in cerebrospinal fluid with SiNiSan Freeze-dry Powder in order to provide dependable evidence about determining that Sini San can enhance the sleep function with drug effect material base. Method: We use HPLC method, the gradient elution, and determine the transmigration ingredient of cerebrospinal fluid in Sini San Freeze-dry Powder.The chromatograph condition: Hypersil C18 column (4.6×250mm,5μm), speed of flow 1.0 ml/min, column warm 28 , flowing A is acetonitrile; Flowing B is 0.05% phosphorus acid water, the analysis time is 140 min. Results: By the analysis of the peak area in cerebrospinal fluid, we found that the endogenous substance in cerebrospinal fluid was increased obviously with Sini San Freeze- dry Powder. From Increasing peak area of the endogenous substance in cerebrospinal fluid, mixing standard preparation's (Paeoniflorin Naringin Saikosaponin C Glycyrrhetinic acid) is 3.2 times Sini San's. onclusion: The specificity and characteristic of the cerebrospinal fluid HPLC fingerprint mark in Sini San are strong, which can use to the transmigration ingredient of cerebrospinal fluid in Sini San Freeze-dry Powder.
The disturbance in cerebrospinal fluid (CSF) circulation is believed to be one of the main causes of hydrocephalus and its variants. Resistance to CSF outflow (Rout) is a parameter, which indicates the degree of CSF disturbance. I is used as supplementary parameter in diagnosing NPH and is calculated by CSF infusion test. During the infusion test, the gradual increase in CSF pressure can be observed. This continuous CSF pressure signal is divided into three phases (i.e. baseline, transient and plateau phases). Rout is calculated by the difference between mean CSF pressure at baseline and plateau phases, divided by the CSF infusion rate. However, currently these phases are designated manually. To minimize inter- or intra operator variability, we suggest automated method which classifies ICP to three sections.
A novel technique to analyze propagation of fluid flow pattern based on magnetic resonance (MR) velocimetry has been developed and applied to cerebrospinal fluid (CSF) dynamics in intracranial space. This technique evaluates spatial distribution of the correlation time as well as correlation coefficient of velocity waveform with respect to an arbitrary reference waveform using quantitative velocity imaging with phase contrast (PC) method. Phantom experiments demonstrated that the propagation of the flow had no delay time because saline was incompressible and the pipes used for the phantom was rigid. In contrast, the propagation of CSF flow in a healthy volunteer appeared to have particular distribution of correlation time indicating that there was delay in the flow. These preliminary results suggest that the technique may yield abundant information concerning on CSF dynamics and thus useful to analyze driving force as well as abnormality in CSF dynamics.
Biomechanically, one of the important roles of the cerebrospinal fluid playing is to provide effective damping against sudden intracranial brain motion during head impact. Thus, the mesh density of cerebrospinal fluid in finite element model needs to be studied because of its significant impact on the brain's biomechanical responses, such as relative displacement. This study based on a previous finite element head model of a 6 years old child developed and validated by the Tianjin University of Science and Technology. The effects of different mesh density of the cerebrospinal fluid on the relative displacement of the brain were studied. The thickness of cerebrospinal fluid remained unchanged but constructed into three layers and one layer of hexahedral elements. The results indicate that the relative displacements of skull-brain in two cases react to impact differently. Relative displacement is higher in the three layers CSF case than that of one layer. Rotational acceleration caused higher relative displacement than translational acceleration for both cases.
Advances in magnetic resonance (MR) imaging techniques enable the accurate measurements of cerebrospinal fluid (CSF) flow in the human brain. In addition, image reconstruction tools facilitate the collection of patient- specific brain geometry data such as the exact dimensions of the ventricular and subarachnoidal spaces (SAS) as well as the computer-aided reconstruction of the CSF-filled spaces. The solution of the conservation of CSF mass and momentum balances over a finite computational mesh obtained from the MR images predict the patients' CSF flow and pressure field. Advanced image reconstruction tools used in conjunction with first principles of fluid mechanics allow an accurate verification of the CSF flow patters for individual patients. This paper presents a detailed analysis of pulsatile CSF flow and pressure dynamics in a normal and hydrocephalic patient. Experimental CSF flow measurements and computational results of flow and pressure fields in the ventricular system, the SAS and brain parenchyma are presented. The pulsating CSF motion is explored in normal and pathological conditions of communicating hydrocephalus. This paper predicts small transmantle pressure differences between lateral ventricles and SASs (~10 Pa). The transmantle pressure between ventricles and SAS remains small even in the hydrocephalic patient (~30 Pa), but the ICP pulsatility increases by a factor of four. The computational fluid dynamics (CFD) results of the predicted CSF flow velocities are in good agreement with Cine MRI measurements. Differences between the predicted and observed CSF flow velocities in the prepontine area point towards complex brain-CSF interactions. The paper presents the complete computational model to predict the pulsatile CSF flow in the cranial cavity
This paper presents a novel mechanism for convenient in vitro measurement of cerebrospinal fluid flow rate in hydrocephalus shunts. Thermal time of flight method has been employed in the measurements conducted on a modified shunt system covered with artificial skin. The shunt tube is proposed to include bio-compatible materials such as titanium for better thermal responses. To facilitate clinical measurements by neurosurgeons, a dry, semiconductor thermoelectric cooling device has been designed to initiate the thermal transfer while maintaining a safe operating temperature and clean thermal excitation. Velocity thus flow rate of the cerebrospinal fluid has been derived by decoupling the thermal transfer in the measured differential time at two measurement spots of the titanium elements. Device design was based on comprehensive system simulation using finite element analyses on the fluidic and thermal behaviors of the shunt system. Microcontroller and proper control schemes have been used for desired thermal excitation and temperature registrations. The mechanism has been validated in measurements conducted on a laboratory setup consisting of the modified shunt, covered by commercial synthetic human skins in an environment similar to human physiology. The measurement results have demonstrated good agreements with the simulation results in the clinically practical flow rates ranging from 0.5 mm/sec to 1.0 mm/sec.
This paper reports for the first time the monitoring of two types of promising biomarkers, beta-amyloid (Aβ42) and total tau (T-tau), in both buffer and cerebrospinal fluid from pooled Human donors for Alzheimer's disease (AD) using label-free optical nanosensors. Experiments found that as low as ~15.6 pg/ml of Aβ42 in buffer can be readily detected by the sensor with very good specificity. Aβ42 spiked in commercially available cerebrospinal fluid (CSF) has been detected successfully. Based on our measurements, the purchased CSF itself contains Aβ42, whose concentration is estimated to be about 400 pg/ml by our measurements. We also have demonstrated the detection of a mixture of Aβ42 and T-tau in CSF successfully, indicating the feasibility of the optical nanosensors to detect these biomarkers in clinic samples.
The subarachnoid space (SAS) contains cerebrospinal fluid (CSF) and a variety of trabeculae that are arranged between the arachnoid mater and the pia layers of the meninges, which stabilizes the shape and the position of the brain during head movements. The complex geometry of subarachnoid trabeculae makes it extremely challenging for the researchers to model the role of them in cerebrospinal fluid (CSF) flow. The goal of this research is to investigate the role of subarachnoid trabeculae in CSF flow, and introduce an alternative model. Three fluid models were created: 1) a model with normal CSF properties, 2) a model with an equivalent fluid, and 3) a modified model having trabeculae as some flow-obstacles. It is found that the trabeculae yield smoother pressure response in a head impact simulation. The sudden pressure changes in SAS are mainly caused by the improvement of the trabeculae anatomy. The study showed that the presence of trabeculae should not be ignored, and the modified model could be used to show heterogeneous distribution of trabeculae in SAS.
Cerebrospinal fluid (CSF) is a fluid that circulates throughout the central nervous system. It is located between the brain and skull and protects the brain and spinal cord from trauma brought upon by movement, falls, blows, etc. More importantly, many of neurological diseases have direct contact with cerebrospinal fluid hydrodynamics and ventricular pressure. Therefore, understanding of the CSF hydrodynamics and ventricular pressure can be very useful for understanding of the pathologic processes and treatment of these diseases. In this study we intend to use a three-dimensional finite element analysis to simulate and investigate this process. For this purpose a fluid- structure interaction analysis of Ansys 12 software has been used. Brain shape modeling was performed using MRI photos in CATIA software.
Accurate estimates of the compliance and outflow resistance of the human cerebrospinal fluid system are important for diagnosis of a medical condition known as hydrocephalus. In this paper we present a system which provides simultaneous on-line estimates of the outflow resistance and compliance. It's performance is experimentally verified using the same apparatus used to perform actual patient diagnoses and a specially designed physical model of the human cerebrospinal fluid system.
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