In vitro

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In vitro refers to studies in experimental biology that are conducted using components of an organism that have been isolated from their usual biological context in order to permit a more detailed or more convenient analysis than can be done with whole organisms. (Wikipedia.org)






Conferences related to In vitro

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2020 IEEE International Conference on Plasma Science (ICOPS)

IEEE International Conference on Plasma Science (ICOPS) is an annual conference coordinated by the Plasma Science and Application Committee (PSAC) of the IEEE Nuclear & Plasma Sciences Society.


2020 IEEE International Magnetic Conference (INTERMAG)

INTERMAG is the premier conference on all aspects of applied magnetism and provides a range of oral and poster presentations, invited talks and symposia, a tutorial session, and exhibits reviewing the latest developments in magnetism.


2020 IEEE International Power Modulator and High Voltage Conference (IPMHVC)

This conference provides an exchange of technical topics in the fields of Solid State Modulators and Switches, Breakdown and Insulation, Compact Pulsed Power Systems, High Voltage Design, High Power Microwaves, Biological Applications, Analytical Methods and Modeling, and Accelerators.


2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII)

The world's premiere conference in MEMS sensors, actuators and integrated micro and nano systems welcomes you to attend this four-day event showcasing major technological, scientific and commercial breakthroughs in mechanical, optical, chemical and biological devices and systems using micro and nanotechnology.The major areas of activity in the development of Transducers solicited and expected at this conference include but are not limited to: Bio, Medical, Chemical, and Micro Total Analysis Systems Fabrication and Packaging Mechanical and Physical Sensors Materials and Characterization Design, Simulation and Theory Actuators Optical MEMS RF MEMS Nanotechnology Energy and Power


2019 41st Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)

The conference program will consist of plenary lectures, symposia, workshops andinvitedsessions of the latest significant findings and developments in all the major fields ofbiomedical engineering.Submitted papers will be peer reviewed. Accepted high quality paperswill be presented in oral and postersessions, will appear in the Conference Proceedings and willbe indexed in PubMed/MEDLINE & IEEE Xplore


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Periodicals related to In vitro

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Antennas and Wireless Propagation Letters, IEEE

IEEE Antennas and Wireless Propagation Letters (AWP Letters) will be devoted to the rapid electronic publication of short manuscripts in the technical areas of Antennas and Wireless Propagation.


Biomedical Circuits and Systems, IEEE Transactions on

The Transactions on Biomedical Circuits and Systems addresses areas at the crossroads of Circuits and Systems and Life Sciences. The main emphasis is on microelectronic issues in a wide range of applications found in life sciences, physical sciences and engineering. The primary goal of the journal is to bridge the unique scientific and technical activities of the Circuits and Systems ...


Biomedical Engineering, IEEE Transactions on

Broad coverage of concepts and methods of the physical and engineering sciences applied in biology and medicine, ranging from formalized mathematical theory through experimental science and technological development to practical clinical applications.


Computational Biology and Bioinformatics, IEEE/ACM Transactions on

Specific topics of interest include, but are not limited to, sequence analysis, comparison and alignment methods; motif, gene and signal recognition; molecular evolution; phylogenetics and phylogenomics; determination or prediction of the structure of RNA and Protein in two and three dimensions; DNA twisting and folding; gene expression and gene regulatory networks; deduction of metabolic pathways; micro-array design and analysis; proteomics; ...


Engineering in Medicine and Biology Magazine, IEEE

Both general and technical articles on current technologies and methods used in biomedical and clinical engineering; societal implications of medical technologies; current news items; book reviews; patent descriptions; and correspondence. Special interest departments, students, law, clinical engineering, ethics, new products, society news, historical features and government.


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Most published Xplore authors for In vitro

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Xplore Articles related to In vitro

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Smart Microrobots for Mechanical Cell Characterization and Cell Convoying

IEEE Transactions on Biomedical Engineering, 2007

This paper deals with the effective design of smart microrobots for both mechanical cell characterization and cell convoying for in vitro fertilization. The first microrobotic device was developed to evaluate oocyte mechanical behavior in order to sort oocytes. A multi-axial micro-force sensor based on a frictionless magnetic bearing was developed. The second microrobotic device presented is a cell convoying device ...


Toward a method for automatic grading of microscope human embryo images

2010 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, 2010

The precise assessment of embryo viability is an extremely important factor for the optimisation of the in vitro fertilisation procedure. In order to assess embryo viability, several embryo scoring systems have been developed. However, they rely mostly on the subjective visual analysis of the embryo morphological features. For instance, an important feature for evaluation of embryos at the day 5 ...


Classification of sperm cells according to their chromosomic content using a neural network trained with a genetic algorithm

Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439), 2003

A priori determination of the sex of a human individual before gestation is a desirable goal in some cases. To achieve this, it is necessary to perform the separation of sperm cells containing either X or Y chromosomes. As is well known, male sex depends on the presence of chromosome Y. Once this separation is achieved in principle, we require ...


Design of a phantom head for the in vitro testing of implantable devices

2007 IEEE 33rd Annual Northeast Bioengineering Conference, 2007

The development of any implant or medical device requires extensive testing. Often in vivo testing is difficult, and sometimes-in the case of neural control devices-impossible. Phantom heads have been constructed in the past for such applications as testing the effects of cellular communication devices, but these models are limited in their utility. The current study is not only aimed at ...


Characterisation of atherosclerotic plaque by spectral analysis of 30 MHz intravascular ultrasound radio frequency data

1996 IEEE Ultrasonics Symposium. Proceedings, 1996

Accurate coronary plaque characterisation by ultrasound would have a major impact on the management of cardiac patients. The aim of this study has been to develop radio-frequency analysis techniques for this purpose. Postmortem coronary arteries (n=5) were imaged with 30 MHz intravascular ultrasound (IVUS) and the raw signals digitised (f=250 MHz) at 11 sites. Spectral parameters were compiled from regions ...


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Educational Resources on In vitro

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IEEE-USA E-Books

  • Smart Microrobots for Mechanical Cell Characterization and Cell Convoying

    This paper deals with the effective design of smart microrobots for both mechanical cell characterization and cell convoying for in vitro fertilization. The first microrobotic device was developed to evaluate oocyte mechanical behavior in order to sort oocytes. A multi-axial micro-force sensor based on a frictionless magnetic bearing was developed. The second microrobotic device presented is a cell convoying device consisting of a wireless micropusher based on magnetic actuation. As wireless capabilities are supported by this microrobotic system, no power supply connections to the micropusher are needed. Preliminary experiments have been performed regarding both cell transporting and biomechanical characterization capabilities under in vitro conditions on human oocytes so as to demonstrate the viability and effectiveness of the proposed setups.

  • Toward a method for automatic grading of microscope human embryo images

    The precise assessment of embryo viability is an extremely important factor for the optimisation of the in vitro fertilisation procedure. In order to assess embryo viability, several embryo scoring systems have been developed. However, they rely mostly on the subjective visual analysis of the embryo morphological features. For instance, an important feature for evaluation of embryos at the day 5 post-fertilisation is the number of cells in the embryo outer layer. In this paper, we present a new method for automation of embryo grading. Based on a polar coordinate version of the input image, we estimated the number of cells in the selected plane of focus using the fractal dimension. A correlation coefficient of 0.81 (n=25) between fractal dimension and the number of cells was found. We also present first segmentation results and highlight challenges that lie ahead.

  • Classification of sperm cells according to their chromosomic content using a neural network trained with a genetic algorithm

    A priori determination of the sex of a human individual before gestation is a desirable goal in some cases. To achieve this, it is necessary to perform the separation of sperm cells containing either X or Y chromosomes. As is well known, male sex depends on the presence of chromosome Y. Once this separation is achieved in principle, we require to determine, with a high degree of accuracy, whether the sperm cells of interest contain the desired X or Y chromosomes. If we are able to obtain certain simple measurements regarding the sperm cells under consideration we will be able to control the fertilization process reliably. In this paper we report a method which allows for non-invasive verification of the characteristics of the separated sperm. We determined a set of easily measurable characteristics. From a sample drawn from previously cropped sperm we trained a neural network with a genetic algorithm. The trained network was able to perform a posteriori classification with an error much smaller than 1%. This percentage of efficiency is better than the ones reported in centers of assisted fecundation.

  • Design of a phantom head for the in vitro testing of implantable devices

    The development of any implant or medical device requires extensive testing. Often in vivo testing is difficult, and sometimes-in the case of neural control devices-impossible. Phantom heads have been constructed in the past for such applications as testing the effects of cellular communication devices, but these models are limited in their utility. The current study is not only aimed at producing a head model fit for the testing of neural control devices, but also at providing a template for future work. By providing the fundamental knowledge of and putting together the framework necessary to designing a phantom, this study generalizes the process such that this method of modeling may be useful for other applications.

  • Characterisation of atherosclerotic plaque by spectral analysis of 30 MHz intravascular ultrasound radio frequency data

    Accurate coronary plaque characterisation by ultrasound would have a major impact on the management of cardiac patients. The aim of this study has been to develop radio-frequency analysis techniques for this purpose. Postmortem coronary arteries (n=5) were imaged with 30 MHz intravascular ultrasound (IVUS) and the raw signals digitised (f=250 MHz) at 11 sites. Spectral parameters were compiled from regions of interest (ROIs=45) within areas of loose fibrotic tissue (DFT), moderate fibrotic tissue (MFT), dense fibrotic tissue (DFT) and calcium (CA), located using scan-converted representations of the data. Power spectra were normalised with respect to a perfect reflector and power- and frequency-related parameters were measured within the bandwidth 17-42 MHz. Significant discrimination between LFT/DFT and LFT/CA was given by maximum power and spectral slope (dB/MHz). The clearest discrimination was provided by the 0 Hz intercept of the spectral slope: LFT/DFT (p<.001); LFT/CA (p<.0001); DFT/CA (p<.1). In order to evaluate the predictive power of these measurements, parametric images were constructed to show the distribution of the plaque types as determined by each parameter.

  • Investigation of cell localisation pattern in 3 dimensional micro-tissues

    It is impossible to mimic mammalian tissues by classical two-dimensional (2D) techniques. In this study, it is aimed to take advantage of self-assembly characteristics of cells in physiological conditions to achieve 3D tissues in vitro. Human Osteosarcoma cells (SaOS-2) were co-cultured with human umbilical vein endothelial cells (HUVEC) and human skin fibroblast cells (Detroit) were co-cultured with human skin keratinocyte cells (HS2) in agar gels that were formed using 3D Petri Dish®technique, and localization of cells were examined. Affect of cell number on localization was also investigated via using different cell ratios in co-culture systems. The change over time in the size of micro-tissues was determined using ImageJ program. The fluorescence microscope examination revealed that in SaOS-2 - HUVEC co-culture system, cells were localized randomly, and there wasn't any significant effect of cell number on localization pattern. In HS2 - Detroit co-culture system, fibroblasts were localized in the core and the keratinocytes were found on the outer shell, and cell number didn't affect this pattern. In microtissues formed by HS2 - Detroit co-culture, there was a significant increase in size after 72 hours. In the SaOS-2 - HUVEC co-culture, there was a significant reduction between the first and the fifth hours.

  • An Improved In Silico Algorithm for Output Visualization of DNA Computing Based on Real-Time PCR

    In the previous paper, a readout approach for the Hamiltonian Path Problem (HPP) in DNA computing based on the real-time polymerase chain reaction (PCR) was proposed. Based on this approach, realtime amplification was performed with the TaqMan probes and the TaqMan detection mechanism was exploited for the design and development of the proposed readout approach. The readout approach consists of two steps: real-time amplification in vitro using TaqMan- based real-time PCR, followed by information processing in silico to assess the results of real-time amplification, which in turn, enables extraction of the Hamiltonian path. The in silico information processing consists an algorithm to extract the Hamiltonian path based on result of in vitro realtime PCR experiment. However, this algorithm indirectly shows the Hamitonian path by only showing the location of each node for the HPP. Thus, in this paper, we modified the previous in silico algorithm such that the Hamiltonian path can be viewed directly after the in silico information processing of the TaqMan reactions based on real-time PCR is implemented. The modified algorithm can be easily implemented in the computerized application.

  • Empirical Software Engineering

    None

  • Parylene coated silicon probes for neural prosthesis

    Silicon neural prosthetic probes require reliable sensing electrodes able to access deep cortical structures without breakage. However, manufacturing limitations have prevented a strong and biocompatible silicon electrode array from reaching this goal. We here demonstrate the first high-density, parylene- coated silicon probe (1.2 cm long) with micro-fabricated electrodes that is able to be inserted in vivo without failure. This work also presents new experimental results for array shank deflection testing, lifetime soak testing as well as the in vitro electrical characterization of the gold and platinum micro-electrodes. These results allow us to optimize the geometry and treatment for both the silicon probe and the metal electrodes.

  • Implantable polycrystalline diamond neural probe for in vivo and in vitro physiological recording

    A second generation (Gen-2) diamond neural probe equipped with both electrical and electrochemical recording abilities is reported for the first time. Fabrication problems related to the high temperature and power requirements associated with diamond growth and the integration of diamond into neural probe technology have been addressed. In this design, polycrystalline diamond (poly-C) is used as the material for the probe's shank and working electrode. Ag/AgCl and gold are used for reference and counter electrodes, respectively. The probe's efficacy for in vivo electrical recording and in vitro electrochemical detection of Norepinephrine ( ~10 muM) is demonstrated.



Standards related to In vitro

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IEEE Standard for Safety Levels with Respect to Human Exposure to Radio Frequency Electromagnetic Fields, 3 kHz to 300 GHz

Recommendations are made to protect against established adverse health effects in human beings associated with exposure to electric, magnetic and electromagnetic fields in the frequency range of 3 kHz to 300 GHz. The recommendations are expressed in terms of basic restrictions (BRs) and maximum permissible exposure (MPE) values. The BRs are limits on internal fields, specific absorption rate (SAR), and ...



Jobs related to In vitro

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