Gene therapy

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inserted into an adenovirus vector, which is used to introduce the modified DNA into a human cell. (Wikipedia.org)






Conferences related to Gene therapy

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2020 IEEE International Conference on Plasma Science (ICOPS)

IEEE International Conference on Plasma Science (ICOPS) is an annual conference coordinated by the Plasma Science and Application Committee (PSAC) of the IEEE Nuclear & Plasma Sciences Society.


2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII)

The world's premiere conference in MEMS sensors, actuators and integrated micro and nano systems welcomes you to attend this four-day event showcasing major technological, scientific and commercial breakthroughs in mechanical, optical, chemical and biological devices and systems using micro and nanotechnology.The major areas of activity in the development of Transducers solicited and expected at this conference include but are not limited to: Bio, Medical, Chemical, and Micro Total Analysis Systems Fabrication and Packaging Mechanical and Physical Sensors Materials and Characterization Design, Simulation and Theory Actuators Optical MEMS RF MEMS Nanotechnology Energy and Power


2019 41st Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)

The conference program will consist of plenary lectures, symposia, workshops andinvitedsessions of the latest significant findings and developments in all the major fields ofbiomedical engineering.Submitted papers will be peer reviewed. Accepted high quality paperswill be presented in oral and postersessions, will appear in the Conference Proceedings and willbe indexed in PubMed/MEDLINE & IEEE Xplore


2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)

Neural Engineering

  • 2017 8th International IEEE/EMBS Conference on Neural Engineering (NER)

    Neural Engineering is an emerging core discipline,which coalesces neuroscience with engineering.Members of both the Neuroscience and Engineering Communities areencouraged to attend this highly multidisciplinarymeeting. The conference will highlight the emergingengineering innovations in the restoration andenhancement of impaired sensory, motor, andcognitive functions, novel engineering for deepeningknowledge of brain function, and advanced designand use of neurotechnologies

  • 2015 7th International IEEE/EMBS Conference on Neural Engineering (NER)

    Neural engineering deals with many aspects of basic and clinical problemsassociated with neural dysfunction including the representation of sensory and motor information, theelectrical stimulation of the neuromuscular system to control the muscle activation and movement, theanalysis and visualization of complex neural systems at multi -scale from the single -cell and to the systemlevels to understand the underlying mechanisms, the development of novel neural prostheses, implantsand wearable devices to restore and enhance the impaired sensory and motor systems and functions.

  • 2013 6th International IEEE/EMBS Conference on Neural Engineering (NER)

    Neural engineering deals with many aspects of basic and clinical problems associated with neural dysfunction including the representation of sensory and motor information, the electrical stimulation of the neuromuscular system to control the muscle activation and movement, the analysis and visualization of complex neural systems at multi-scale from the single-cell and to the system levels to understand the underlying mechanisms, the development of novel neural prostheses, implants and wearable devices to restore and enhance the impaired sensory and motor systems and functions.

  • 2011 5th International IEEE/EMBS Conference on Neural Engineering (NER)

    highlight the emerging field, Neural Engineering that unites engineering, physics, chemistry, mathematics, computer science with molecular, cellular, cognitive and behavioral neuroscience and encompasses such areas as replacing or restoring lost sensory and motor abilities, defining the organizing principles and underlying mechanisms of neural systems, neurorobotics, neuroelectronics, brain imaging and mapping, cognitive science and neuroscience.

  • 2009 4th International IEEE/EMBS Conference on Neural Engineering (NER)

    highlight the emerging field, Neural Engineering that unites engineering, physics, chemistry, mathematics, computer science with molecular, cellular, cognitive and behavioral neuroscience and encompasses such areas as replacing or restoring lost sensory and motor abilities, defining the organizing principles and underlying mechanisms of neural systems, neurorobotics, neuroelectronics, brain imaging and mapping, cognitive science and neuroscience.

  • 2007 3rd International IEEE/EMBS Conference on Neural Engineering

  • 2005 2nd International IEEE/EMBS Conference on Neural Engineering

  • 2003 1st International IEEE/EMBS Conference on Neural Engineering


2019 IEEE International Ultrasonics Symposium (IUS)

The conference covers all aspects of the technology associated with ultrasound generation and detection and their applications.


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Periodicals related to Gene therapy

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Applied Superconductivity, IEEE Transactions on

Contains articles on the applications and other relevant technology. Electronic applications include analog and digital circuits employing thin films and active devices such as Josephson junctions. Power applications include magnet design as well asmotors, generators, and power transmission


Biomedical Engineering, IEEE Transactions on

Broad coverage of concepts and methods of the physical and engineering sciences applied in biology and medicine, ranging from formalized mathematical theory through experimental science and technological development to practical clinical applications.


Computational Biology and Bioinformatics, IEEE/ACM Transactions on

Specific topics of interest include, but are not limited to, sequence analysis, comparison and alignment methods; motif, gene and signal recognition; molecular evolution; phylogenetics and phylogenomics; determination or prediction of the structure of RNA and Protein in two and three dimensions; DNA twisting and folding; gene expression and gene regulatory networks; deduction of metabolic pathways; micro-array design and analysis; proteomics; ...


Computers, IEEE Transactions on

Design and analysis of algorithms, computer systems, and digital networks; methods for specifying, measuring, and modeling the performance of computers and computer systems; design of computer components, such as arithmetic units, data storage devices, and interface devices; design of reliable and testable digital devices and systems; computer networks and distributed computer systems; new computer organizations and architectures; applications of VLSI ...


Control Systems Technology, IEEE Transactions on

Serves as a compendium for papers on the technological advances in control engineering and as an archival publication which will bridge the gap between theory and practice. Papers will highlight the latest knowledge, exploratory developments, and practical applications in all aspects of the technology needed to implement control systems from analysis and design through simulation and hardware.


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Xplore Articles related to Gene therapy

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Dynamics modeling and analysis of gene guns for gene therapy

Proceedings 2006 IEEE International Conference on Robotics and Automation, 2006. ICRA 2006., 2006

The gene gun is an important apparatus for continuous gene transfection and is widely regarded as a common delivery device for gene therapy. The gene transfer process is a highly dynamics process. To achieve effective treatment, the gene transfer process needs to be well understood and controlled. Unfortunately, no dynamics model is available to analyze the process in the literature. ...


A high voltage amplifier for use in medical applications of electroporation

Proceedings First IEEE International Workshop on Electronic Design, Test and Applications '2002, 2002

The bio-physical effect known as electroporation or electropermeabilization is becoming more widely used in medical treatment, especially for chemotherapy and gene therapy. The conventional electrical apparatus used is based on DC voltage pulses which may not be optimal. Indications are that AC pulses may provide significant improvements. A high voltage linear amplifier design incorporating vacuum tube valves is presented that ...


Quantitative relations between acoustic inertial cavitation and gene transfection rate/cell viability

IEEE Ultrasonics Symposium, 2005., 2005

None


The potential role of synthetic biology in manufacturing of regenerative medicine

IET/SynbiCITE Engineering Biology Conference, 2016

In this paper, many challenges remain in bringing regenerative medicine to the mass market; safety, efficacy,reproducibility and affordability of such therapies are some of the considerations. This review explores the possible roles that synthetic biology may be able to play in overcoming some of these challenges.


N-Butyltriphenylphosphonium Bromide-linear PEI Polymers Mediated Efficient Gene Transfection

2013 29th Southern Biomedical Engineering Conference, 2013

Gene therapy has inspired various researchers due to its potential of treating inherited disorders; however, many problems remain to be resolved such as development of a safe and efficient vector to overcome major hurdles of the gene transfer at the cellular level. To address these issues, various modifications have been incorporated in cationic polymers. Among these, hydrophobic modifications have also ...


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Educational Resources on Gene therapy

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IEEE.tv Videos

The New Gene Therapy: CRISPR CAS-9 and the Future of Medicine: IEEE VICS 2018
Robots and Gaming - Therapy for Children with Disabilities
IMS 2011 Microapps - Application Principles for Circulators and Isolators
EMBC 2011-Course-Virtual Reality and Robotics in Neurorehabilitation-Susan Fasoli
IEEE Sections Congress 2011 - vTools
Perpendicular magnetic anisotropy: From ultralow power spintronics to cancer therapy
Applying Control Theory to the Design of Cancer Therapy
EPICS In IEEE Spotlight - NJIT 2016 Project
The Use of Robotic and Advanced Technology in Neurorehabilitation
Sean Sliger of Neuropace accepts the IEEE Spectrum Technology in the Service of Society Award - Honors Ceremony 2016
Roozbeh Ghaffari of MC10 accepts the IEEE Spectrum Emerging Technology Award - Honors Ceremony 2016
ICASSP 2010 - Advances in Neural Engineering
Implantable, Insertable and Wearable Micro-optical Devices for Early Detection of Cancer - Plenary Speaker, Christopher Contag - IPC 2018
Moving into the Future with Smart Medicine: Thomas Schmitz-Rode
Working Panel Wrap-Up On Advancing The Solutions - Global Connect Stakeholders: Advancing Solutions
Magnetic Nanowires: Revolutionizing Hard Drives, RAM, and Cancer Treatment
EMBC 2011 -Keynote (Women in Engineering Program) Re-engineering the War on Cancer: A Call to Action for Personalized Medicine -Mara G. Aspinall
Gender-Based Occupational Stereotypes: New Behaviors, Old Attitudes - Carolyn Matheus & Elizabeth Quinn - IEEE WIE Forum USA East 2017

IEEE-USA E-Books

  • Dynamics modeling and analysis of gene guns for gene therapy

    The gene gun is an important apparatus for continuous gene transfection and is widely regarded as a common delivery device for gene therapy. The gene transfer process is a highly dynamics process. To achieve effective treatment, the gene transfer process needs to be well understood and controlled. Unfortunately, no dynamics model is available to analyze the process in the literature. In this paper, a dynamics model of the gene gun is proposed. Based on the mathematical model, simulation studies have been conducted. Relations of penetration depth with helium pressure, acceleration distance, macro- carrier mass, and micro-carrier radius are discussed. The results agree well with experimental results in the literature

  • A high voltage amplifier for use in medical applications of electroporation

    The bio-physical effect known as electroporation or electropermeabilization is becoming more widely used in medical treatment, especially for chemotherapy and gene therapy. The conventional electrical apparatus used is based on DC voltage pulses which may not be optimal. Indications are that AC pulses may provide significant improvements. A high voltage linear amplifier design incorporating vacuum tube valves is presented that could facilitate AC pulse experimentation. Valves are used as they most readily suit the desired electrical specifications of an output voltage of 4kV/sub p/, a bandwidth of 500 Hz-5 MHz, a voltage gain of 52 dB, and an output impedance of <100 /spl Omega/.

  • Quantitative relations between acoustic inertial cavitation and gene transfection rate/cell viability

    None

  • The potential role of synthetic biology in manufacturing of regenerative medicine

    In this paper, many challenges remain in bringing regenerative medicine to the mass market; safety, efficacy,reproducibility and affordability of such therapies are some of the considerations. This review explores the possible roles that synthetic biology may be able to play in overcoming some of these challenges.

  • N-Butyltriphenylphosphonium Bromide-linear PEI Polymers Mediated Efficient Gene Transfection

    Gene therapy has inspired various researchers due to its potential of treating inherited disorders; however, many problems remain to be resolved such as development of a safe and efficient vector to overcome major hurdles of the gene transfer at the cellular level. To address these issues, various modifications have been incorporated in cationic polymers. Among these, hydrophobic modifications have also been considered; however, such modifications affect the solubility of the polymers post modification. In an attempt overcome this concern, we have deliberately selected a hydrophobic ligand bearing a charged moiety, i.e. Butyltriphenylphosphonium bromide (TPP<sup>+</sup>). A series of triphenylphosphonium bromide-grafted-linear polyethylenimine (BTP) polymers have been synthesized and characterized by physicochemical techniques prior to their evaluation for transfection efficacy and cytotoxicity. Subsequently, the BTP polymers were assessed for their buffering capacity, intracellular trafficking and transfection studies in mammalian cell lines and found to exhibit significantly higher transfection efficiency compared to the standard transfection reagents. The versatility of the projected vector was established by sequential delivery of GFP-specific siRNA, which resulted in efficient knockdown of the targeted gene expression. The study demonstrates that the BTP polymers can serve as efficient vectors for the delivery of nucleic acids in future gene therapy applications.

  • Interaction of nanostructured polyelectrolyte complexes with cells

    Gene therapy is a technique in which nucleic acids are introduced into cells with the purpose to alter the course of a medical condition or disease. Due to its negative charge and its large hydrodynamic volume, free DNA is not taken up in cells very efficiently. To overcome this problem, the DNA can be combined with a vector. One of the topics our research groups is focussing on is the synthesis and evaluation of cationic polymers that can be used as a gene delivery system. Starting from a series of cationic amine containing polymers, we observed large differences in transfection efficiency. To further study these findings, we carried out interaction studies of polymer-DNA complexes and GAG. Complexes showing a lower stability towards GAG, also possess a low transfection efficiency. These findings were also confirmed by cell uptake studies, showing that complexes showing high levels of transfection are taken up in cells efficiently.

  • Tissue-engineered microvascular networks for gene therapy made from adult endothelial and endothelial progenitor cells

    From their location at the internal surface of blood vessels, endothelial cells may provide a useful site from which to efficiently deliver therapeutic proteins to the circulation. High-passage bovine aortic endothelial cells (BAEC) in Matrigel cultured in vitro remain spherical and decrease in number over time while those mixed with fibroblasts (FB) show improved survival and form interconnected microvascular networks (MVN) in vitro. Inclusion of FB with high-passage, hGH-secreting BAEC in Matrigel prolongs survival and systemic delivery of hGH when gels are implanted subcutaneously in nude mice. The challenge remains to increase and prolong endothelial cell incorporation into blood vessels. Low-passage BAEC alone in Matrigel form MVN and inclusion of fibroblasts potentiates their MVN formation. Endothelial progenitor cells derived from adult human peripheral blood (BOEC) differentiate into endothelial cells while maintaining a large proliferative capacity and may retain their stem-cell characteristics. BOEC suspended in Matrigel and cultured in vitro remain spherical while those mixed with fibroblasts elongate and form interconnected microvascular networks in vitro. Further, BOEC cultured in collagen in the presence of PMA also formed MVN and created lumen- like structures.

  • Towards image-guided gene therapy delivery

    Image-guided procedures have grown steadily over the past decade. In most the aim is the resection or destruction of diseased tissue. Gene therapy agents have a very limited diffusion distance which limits their usefulness. A technique for guiding the delivery of gene therapy using image-guidance is under development. When complete, it would allow the delivery of diffusion limited therapies to a broad volume. We present the results of the delivery system development and the accuracy testing.

  • Electroporation of single cells by high frequency shocks

    This modeling study investigates electroporation in a single cell exposed to a 10 ms pulse train consisting of high frequency monophasic or biphasic shocks. The fraction of the cell membrane occupied by pores decreases with frequency, and the decrease is more gradual for monophasic pulses. This result suggests that varying the frequency of the monophasic pulse train may provide control over the uptake of molecules during electroporation-mediated drug and gene therapies.

  • Preparation of MSCs Alginate-based Microcapsules for Gene Therapy

    Transplantation of microencapsulated transgenic mesenchymal stem cells (MCSs) is proposed as a gene therapy for the treatment of a wide variety of diseases since it allows for transplantation of endocrine cells in the absence of undesired immunosuppression as well as limited cell sources. Firstly, Alginate-Poly-L-Lysine (PLL) microcapsules were obtained using purified and non-purified sodium alginate respectively and their biocompatibility and membrane mechanical intensity were compared to investigate the necessity of purification of sodium alginate. Moreover, Alginate-Chitosan microcapsules were prepared as well as process optimization. The results showed the obviously improved biocompatibility and the membrane mechanical intensity o f purified sodium alginate-based microcapsules. Lastly, the MSCs loaded Alginate-Chitosan with good morphology microcapsules could be obtained using purified sodium alginate and chitosans of medium-molecular weight (1.0 ~ 2.5 times 10<sup>5</sup>) under optimal condition. The optimal preparation technological parameters were chitosan solution of 0.1% (w/v) and 7-min-long reaction time between alginate and chitosan (5-10 min).



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