1,207 resources related to Peptides
- Topics related to Peptides
- IEEE Organizations related to Peptides
- Conferences related to Peptides
- Periodicals related to Peptides
- Most published Xplore authors for Peptides
IEEE International Conference on Plasma Science (ICOPS) is an annual conference coordinated by the Plasma Science and Application Committee (PSAC) of the IEEE Nuclear & Plasma Sciences Society.
To promote awareness, understanding, advancement and application of ocean engineering and marine technology. This includes all aspects of science, engineering, and technology that address research, development, and operations pertaining to all bodies of water. This includes the creation of new capabilities and technologies from concept design through prototypes, testing, and operational systems to sense, explore, understand, develop, use, and responsibly manage natural resources.
The world's premiere conference in MEMS sensors, actuators and integrated micro and nano systems welcomes you to attend this four-day event showcasing major technological, scientific and commercial breakthroughs in mechanical, optical, chemical and biological devices and systems using micro and nanotechnology.The major areas of activity in the development of Transducers solicited and expected at this conference include but are not limited to: Bio, Medical, Chemical, and Micro Total Analysis Systems Fabrication and Packaging Mechanical and Physical Sensors Materials and Characterization Design, Simulation and Theory Actuators Optical MEMS RF MEMS Nanotechnology Energy and Power
The conference program will consist of plenary lectures, symposia, workshops andinvitedsessions of the latest significant findings and developments in all the major fields ofbiomedical engineering.Submitted papers will be peer reviewed. Accepted high quality paperswill be presented in oral and postersessions, will appear in the Conference Proceedings and willbe indexed in PubMed/MEDLINE & IEEE Xplore
The IEEE International Symposium on Biomedical Imaging (ISBI) is the premier forum for the presentation of technological advances in theoretical and applied biomedical imaging.ISBI 2019 will be the 16th meeting in this series. The previous meetings have played a leading role in facilitating interaction between researchers in medical and biological imaging. The 2019 meeting will continue this tradition of fostering cross fertilization among different imaging communities and contributing to an integrative approach to biomedical imaging across all scales of observation.
The IEEE Reviews in Biomedical Engineering will review the state-of-the-art and trends in the emerging field of biomedical engineering. This includes scholarly works, ranging from historic and modern development in biomedical engineering to the life sciences and medicine enabled by technologies covered by the various IEEE societies.
Broad coverage of concepts and methods of the physical and engineering sciences applied in biology and medicine, ranging from formalized mathematical theory through experimental science and technological development to practical clinical applications.
Specific topics of interest include, but are not limited to, sequence analysis, comparison and alignment methods; motif, gene and signal recognition; molecular evolution; phylogenetics and phylogenomics; determination or prediction of the structure of RNA and Protein in two and three dimensions; DNA twisting and folding; gene expression and gene regulatory networks; deduction of metabolic pathways; micro-array design and analysis; proteomics; ...
Physics, medicine, astronomy—these and other hard sciences share a common need for efficient algorithms, system software, and computer architecture to address large computational problems. And yet, useful advances in computational techniques that could benefit many researchers are rarely shared. To meet that need, Computing in Science & Engineering (CiSE) presents scientific and computational contributions in a clear and accessible format. ...
Both general and technical articles on current technologies and methods used in biomedical and clinical engineering; societal implications of medical technologies; current news items; book reviews; patent descriptions; and correspondence. Special interest departments, students, law, clinical engineering, ethics, new products, society news, historical features and government.
IEEE Transactions on Nuclear Science, 1993
Capillary electrophoresis (CE) is an instrumental technique capable of high resolution separation and analysis of small quantities of nucleotides, amino acids, peptides, and proteins with very high efficiency and throughput. The unprecedented sensitivity of this technique will be useful for such new applications as in vivo labeling and identification of trace substances and single cell work. The principal limitation of ...
2007 IEEE 33rd Annual Northeast Bioengineering Conference, 2007
Gramicidin is a pore-forming peptide which exhibits lethal properties against a large spectrum of cells. It forms monovalent cation-specific channel in the lipid bilayer of a cellular membrane with limited permeability to anions or polyvalent cations. Both ions and water move through the pore which is formed by the peptide backbone. We detected formation of pores induced by the dimerization ...
Proceedings of the First Joint BMES/EMBS Conference. 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Annual Fall Meeting of the Biomedical Engineering Society (Cat. N, 1999
T cell activation requires formation of a specialized cell-cell junction, the immunological synapse (Paul and Seder, 1994). The authors have hypothesized that segregation will be an important process for T cell activation (Shaw and Dustin, 1997). To test these hypotheses and to explore the engineering principles behind these events the authors have developed a model system in which formation of ...
2007 Frontiers in the Convergence of Bioscience and Information Technologies, 2007
Molecular mimicry defined as similar structures shared by molecules from dissimilar genes or by their protein products, is a general strategy for pathogens to infect host cells. Therefore, identification of the molecular mimic regions of a pathogen may be helpful to understand the disease. Severe acute respiratory syndrome (SARS) is a new human respiratory infectious disease caused by SARS coronavirus ...
2010 Third International Conference on Information and Computing, 2010
The complex Interconnections between markers and polygenic genotype value suggested that the regression was not enough for describing the relation between genes and traits. Artificial neural networks (ANNs) could perform well for optimization in complex non-linear systems. Recently, artificial neural networks had been successfully used to predict the polygenic genotype value, and the different learning rate and hidden neurons number ...
Capillary electrophoresis (CE) is an instrumental technique capable of high resolution separation and analysis of small quantities of nucleotides, amino acids, peptides, and proteins with very high efficiency and throughput. The unprecedented sensitivity of this technique will be useful for such new applications as in vivo labeling and identification of trace substances and single cell work. The principal limitation of this technique for radiolabeled molecules has been identified as the sensitivity of the detector, primarily due to the small sample volume (<1 nl) and the short residence time of the sample in the detector (<3 sec). The authors report the development of a high- sensitivity CdTe solid-state detector used for detection of /sup 32/P-labeled biomolecules with unprecedented sensitivity. This detector can be easily retrofitted into existing CE apparatus.<>
Gramicidin is a pore-forming peptide which exhibits lethal properties against a large spectrum of cells. It forms monovalent cation-specific channel in the lipid bilayer of a cellular membrane with limited permeability to anions or polyvalent cations. Both ions and water move through the pore which is formed by the peptide backbone. We detected formation of pores induced by the dimerization of gramicidin molecules by monitoring changes in the membrane and action potentials of neurons in the central nervous system of Lymnaea stagnalis. This methodology could be used for the study of peptide interactions with neuronal cellular membranes.
T cell activation requires formation of a specialized cell-cell junction, the immunological synapse (Paul and Seder, 1994). The authors have hypothesized that segregation will be an important process for T cell activation (Shaw and Dustin, 1997). To test these hypotheses and to explore the engineering principles behind these events the authors have developed a model system in which formation of an immunological synapse is quantitatively visualized in real time. Molecular segregation of engaged MHC-peptide and ICAM-1 complexes was strongly correlated with T cell proliferation. These data support the hypothesis that molecular segregation is important for T cell signaling.
Molecular mimicry defined as similar structures shared by molecules from dissimilar genes or by their protein products, is a general strategy for pathogens to infect host cells. Therefore, identification of the molecular mimic regions of a pathogen may be helpful to understand the disease. Severe acute respiratory syndrome (SARS) is a new human respiratory infectious disease caused by SARS coronavirus (SARS-CoV). The virus uses the spike (S) protein to interact with the angiotensin converting enzyme 2, the host cell receptor. Our approach is to design a workflow with multiple bioinformatics tools in analyzing the sequence of spike protein of the SARS-CoV in searching its similarity to human proteins. Furthermore, eleven peptides have been synthesized to validate the in silico results.
The complex Interconnections between markers and polygenic genotype value suggested that the regression was not enough for describing the relation between genes and traits. Artificial neural networks (ANNs) could perform well for optimization in complex non-linear systems. Recently, artificial neural networks had been successfully used to predict the polygenic genotype value, and the different learning rate and hidden neurons number were used to discuss the influencing of the learning rate on estimating the polygenic genotype value. However, when optimazing the structure of BP-artificial neural networks, a series of networks with an variable number of hidden neurons and input neuron needs to be optimized, compared and selected, the elapsed time could be very long, therefore the elapsed time was very important for work efficients. In this paper, the influence of different gene parameter nomorlization on back-propagation artificial neural network caculating time of animal phenotype value pretiction was discussed. The results showed that the caculating time could be affected by many gene parameters, such as the gene effect, gene locus number, gene frequency, and their nomorlization, the normorlization can improve the training speed and induce absolute time or elapsed time very obviously. These suggested that normalizing the phenotype value was an very important method for improving our work efficient.
Proteasomes in the immune response play vital roles. The antigen proteins are first degraded into peptides by some proteasomes; then some of the peptides will bind with specific MHC molecules and then be presented to T cells to activate the immune response. It is known that some artificial peptides cannot activate T cell response even though they can bind with MHC molecules. Therefore, whether the peptides are naturally generated by proteasome protein degradation process is very important to be the T cell epitopes. In this paper, we try to address the issue of predicting which peptides are naturally generated by predicting the proteasome cleavage sites, and present a rough set theory based prediction method. The experimental results show that our method has good performances in terms with the prediction accuracy and the understandable rules.
The polysaccharide dextran, prepared as a colloid suspension in physiological saline, is routinely used as a plasma extender or substitute for emergency treatment of massive blood and fluid loss in settings where blood and blood products are not readily available. The objective of this study is to develop a dextran-peptide conjugate that selectively self-assembles onto injured tissue surfaces to form a protective colloid barrier against trauma-induced systemic inflammatory cell damage to healthy tissues. Endothelial cells were treated in vitro with a CD11b/CD18 antagonist conjugated to dextran. This agonist peptide conjugated to dextran decreased monocyte adhesion to TNF /spl alpha/-activated endothelium more effectively than peptide alone. The scrambled version of the same peptide, conjugated and not, did not block monocyte adhesion in similarly activated endothelium. These studies indicate that an CD11b/CD18 antagonist dextran conjugate that is delivered introvascularly may limit organ damage following intestinal ischemia and reperfusion injury.
The neural stem cells were induced by low-level dopamine (DA). We allowed cells 72 h of differentiation before protein extraction. The global proteins of neural stem cells and dopaminergic neurons were extracted. In this study, the protein from cell lysat was rudiment separated by SDS-PAGE, and the gel strip was cut into several portions. The protein in each portion is digested by trypsin, and then the peptides mixtures were analyzed by mass spectrometry (LC-MS/MS). 839 proteins in the neural stem cells and 718 proteins in the dopaminergic neuron were identified. The nestin protein was found in the NSCs and the Sodium-dependent dopamine transporter (DA transporter)(DAT) was found in the dopaminergic neuron which was induced by low level DA. The cytoskeletal proteins rearranged after the NSCs differentiated and regulating proteins changed a lot.
The integration of complex, fast changing biological data repositories can be potentially supported by Grid computing to enable distributed data analysis. The ISPIDER proteomics Grid provides an architecture supporting the combined use of Grid data access, Grid distributed querying and data integration software tools, which support distributed, heterogeneous biologic data integration and analysis. This paper introduces the ISPIDER Proteomics Grid, and discusses what kind of metadata can be used for expressing the multiplicity of data models and the data transformation and integration processes in the proteomics integration Grid, and how this metadata can be further used for supporting other data integration activities.
Summary form only given: Congestive heart failure is a leading cause of morbidity and mortality in the United States and worldwide. Although not the only cause of congestive heart failure, loss of myocardium due to obstructive coronary artery disease is a major contributor to this condition. The loss of myocardium is mainly regional and, therefore, localized therapy holds the most promise. In recent years, many clinical studies have been initiated to deliver localized therapy in the form of various cell types for reconstitution of the myocardium. However, there is much debate on the optimal cell type, whether or not stem cells can differentiate into functional myocardium and the long-term effects of these non-myocytes. In addition to exogenous cell delivery, paracrine effects arising from delivery of angiogenic factors and other biochemical agents suggest that the myocardium retains the ability to remodel and heal. Understandably, there has been tremendous focus on both growth factor- and gene therapy-based therapeutics. While a source of great promise, direct growth factor delivery to the myocardium will most likely be inefficient as several studies have noted that many of these small proteins are carried away in the highly vascularized cardiac tissue. Gene therapy, while providing an excellent analytical tool, has not met with enthusiasm clinically, mostly due to the inability to quantify delivery and nonspecific targeting in vivo. This body of work supports two crucial conclusions: (1) appropriate biological cues that act locally on the myocardium can improve functional outcomes, and (2) spatiotemporal control over the delivery and presentation of these cues remains challenging and inefficient. The current body of work on cardiac drug delivery and stem cell therapy support two crucial conclusions: (1) appropriate biological cues that act locally on the myocardium can improve functional outcomes, and (2) spatiotemporal control over the delivery and presentation of these cues remains challenging and inefficient. Using specialized biomaterials, we are able to address this. Our laboratory has used functional nanoparticles to deliver regenerative cues with both spatial and temporal control. By adding biomimetic signals to the surface of the nanoparticles, we are able to enhance nonphagocytic cell uptake, achieve cell-specific targeting, and deliver molecules in a time-controlled manner. Furthermore, by combining our nanoparticles with self-assembling peptide nanofibers, we can achieve some of these in 3D while retaining implanted cells. Following infarction, and during cell differentiation and survival, there are unique sequences of events that contribute to the pathophysiology of the processes. By enhanced understanding of these signals, and the spatiotemporal control needed to deliver them, it will help design better therapeutics for cardiac regeneration. Using high-throughput screening, we have identified several carbohydrates that bind with high affinity to both cardiomyocytes and cardiac progenitor cells. For example, n-acetylglucasmine (GlcNAc) and related sugars bound with high affinity to both of these important cell types. Modification of the sugars with phospholipds allowed incorporation of into hydrophobic nanoparticles with high fidelity. When delivered to cardiomyocytes or cardiac progenitor cells, these biologically- modified nanoparticles enhanced uptake by several fold. In addition to using sugars, we also used metal affinity chromatography chemistry to link Nickel- NTA to the outside of nanoparticles. This not only allowed for conjugation of Histidine-tagged proteins to the outside for temporal delivery, but also allowed for conjugation of cell-specific targeting agents as well. Indeed, when His-VE-Cadherin was used as a model targeting agent, binding and uptake by endothelial cells increased significantly. For cell therapy, incorporation of proper signals to the micoenvironment is critical. One such signal that greatly impacts differentiation is the Notch1 pathway. We were able to immobilize Jagged1, the ligand of Notch1, on to self-assembling peptide nanofibers. Inclusion of this bioactive signal significantly enhanced cardiogenic differentiation. Morever, by including time release nanoparticles, we were able to improve differentiation and survival significantly more, underscoring the need to spatiotemporal control of drug delivery for enhancing cell therapy.
No standards are currently tagged "Peptides"